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In pursuit of this goal, we have developed and synthesized a new series of rhodanine\u2010linked enamine\u2013carbohydrazide derivatives, exploring their potential as inhibitors of mycobacterial carbonic anhydrase. The findings reveal their efficacy, displaying notable selectivity toward the mycobacterial carbonic anhydrase 2 (mtCA 2) enzyme. While exhibiting moderate activity against human carbonic anhydrase isoforms, this series demonstrates promising selectivity, positioning these compounds as potential antitubercular agents. Compound <jats:bold>6d<\/jats:bold> was the best one from the series with a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 9.5\u2009\u00b5M toward mtCA 2. Most of the compounds displayed moderate to good inhibition against the Mtb H37Rv strain; compound <jats:bold>11k<\/jats:bold> showed a minimum inhibitory concentration of 1\u2009\u00b5g\/mL. Molecular docking studies revealed that compounds <jats:bold>6d<\/jats:bold> and <jats:bold>11k<\/jats:bold> show metal coordination with the zinc ion, like classical CA inhibitors.<\/jats:p>","DOI":"10.1002\/ardp.202400064","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T21:09:41Z","timestamp":1710796181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring rhodanine linked enamine\u2013carbohydrazide derivatives as mycobacterial carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and molecular docking studies"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9828-1124","authenticated-orcid":false,"given":"Sarvan","family":"Maddipatla","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER), Balanagar Hyderabad Telangana 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