{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:32:41Z","timestamp":1790098361099,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The design and synthesis of a library of 21 novel benzenesulfonamide\u2010bearing 3\u2010functionalized pyrazole\u2010linked 1,2,3\u2010triazole derivatives as dual inhibitors of cathepsin B and carbonic anhydrase enzymes are reported. The target 1,2,3\u2010triazole\u2010linked pyrazolic esters (\n                    <jats:bold>16<\/jats:bold>\n                    ) were synthesized by the condensation of 1,2,3\u2010triazolic diketo esters with 4\u2010hydrazinobenzenesulfonamide hydrochloride, and these were further converted into the corresponding carboxylic acid (\n                    <jats:bold>17<\/jats:bold>\n                    ) and carboxamide (\n                    <jats:bold>18<\/jats:bold>\n                    ) analogs. The synthesized compounds were assayed in vitro for their inhibition potential against human carbonic anhydrase (hCA) isoforms I, II, IX, and XII. They were found to be potent inhibitors at the low nanomolar level against the cancer\u2010related hCA IX and XII and to be selective towards the cytosolic isoform hCA I. The physiologically important isoform hCA II was potently inhibited by all the newly synthesized compounds showing\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>I<\/jats:sub>\n                    values ranging between 0.8 and 561.5\u2009nM. The ester derivative\n                    <jats:bold>16c<\/jats:bold>\n                    having 4\u2010fluorophenyl (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>I<\/jats:sub>\n                    \u2009=\u20095.2\u2009nM) was the most potent inhibitor of hCA IX, and carboxamide derivative\n                    <jats:bold>18b<\/jats:bold>\n                    (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>I<\/jats:sub>\n                    \u2009=\u20092.2\u2009nM) having 4\u2010methyl substituted phenyl was the most potent inhibitor of hCA XII. The newly synthesized compounds exhibited potent cathepsin B inhibition at 10\n                    <jats:sup>\u22127<\/jats:sup>\n                    \u2009M concentration. In general, the carboxamide derivatives (\n                    <jats:bold>18<\/jats:bold>\n                    ) showed higher % inhibition as compared with the corresponding ester derivatives (\n                    <jats:bold>16<\/jats:bold>\n                    ) and carboxylic acid derivatives (\n                    <jats:bold>17<\/jats:bold>\n                    ) for cathepsin B. The interactions of the target compounds with the active sites of cathepsin B and CA were studied through molecular docking studies. Further, the in silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) and drug\u2010likeness properties of the target compounds were also studied.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202400114","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T11:54:43Z","timestamp":1718884483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Benzenesulfonamides functionalized with triazolyl\u2010linked pyrazoles possess dual cathepsin B and carbonic anhydrase inhibitory action"],"prefix":"10.1002","volume":"357","author":[{"given":"Kiran","family":"Siwach","sequence":"first","affiliation":[{"name":"Department of Chemistry Kurukshetra University Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit","family":"Vats","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University Kurukshetra Haryana India"},{"name":"Department of Chemistry Government College Bherian, Pehowa Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University Kurukshetra Haryana India"},{"name":"Pt. Chiranji Lal Sharma Government College Karnal Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Giovannuzzi","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Pharmaceutical and Nutraceutical Section University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neera","family":"Raghav","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Pharmaceutical and Nutraceutical Section University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University Kurukshetra Haryana India"},{"name":"Department of Chemistry Central University of Haryana Mahendergarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071150"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1743676"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051045"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20045667"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.672983"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo7030048"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986706777935122"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.07.024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201300105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.02.035"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-013-0872-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2016.05.003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2014.04.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.06.021"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.03.030"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.02.023"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2077333"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200391"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200439"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112439"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.05.037"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.08.006"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmcr.2022.100056"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crgsc.2022.100295"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202300372"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62326-9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202300349"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-019-0362-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci500209e"},{"key":"e_1_2_8_34_1","unstructured":"C.Huber 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