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The present investigation aimed to develop a self\u2010microemulsifying drug delivery system (SMEDDS) of PZH using a blend of Capryol\u00ae 90, Labrasol\u00ae, and propylene glycol to improve its solubility. Furthermore, a sustained\u2010release SMEDDS\u2010based gastroretentive floating system was developed and optimized using the Central Composite Design approach of DoE. The optimized SMEDDS\u2010based in situ gelling raft, R\u2010SM\u2010PZH, exhibited minimal floating lag time (3.09\u2009\u00b1\u20090.8\u2009s), optimal viscosity (1229.4\u2009\u00b1\u200920.9\u2009cP) and density (0.327\u2009\u00b1\u20090.15\u2009g\/mL) as compared to other formulations under study. Additionally, R\u2010SM\u2010PZH was evaluated for its in vitro dissolution in FaSSGF and FeSSGF, pharmacokinetic profile, and MTT assay (against NCI\u2010H460 lung cancer cells) compared to pure PZH. A 12 h sustained release, three\u2010fold augmentation in dissolution rate and bioavailability, and 15\u2010fold enhancement in cytotoxicity were observed in comparison to pure PZH. Thus, the SMEDDS\u2010based in situ gelling raft presents a promising approach to advancing the developability potential of PZH.<\/jats:p>","DOI":"10.1002\/ardp.202400179","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T05:47:04Z","timestamp":1729835224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Self\u2010microemulsifying drug delivery system\u2010based gastroretentive in situ raft of pazopanib with enhanced solubility and bioavailability"],"prefix":"10.1002","volume":"358","author":[{"given":"Vridhi","family":"Sachdeva","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshula","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurdeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Botanical and Environmental Sciences Guru Nanak Dev University Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6403-6289","authenticated-orcid":false,"given":"Neena","family":"Bedi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University Amritsar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2021.103829"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jadpro.2013.4.1.6"},{"key":"e_1_2_8_5_1","unstructured":"V.Beljanski inxPharm: The Comprehensive Pharmacology Reference(Eds:S. 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