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The final compounds were tested for their ability to inhibit acetylcholinesterase and butyrylcholinesterase, and the in vitro dissolution behavior of selected compounds was studied through both lipophilic and hydrophilic matrix tablets. All nine tested derivatives were even more active in inhibiting acetylcholinesterase than the clinically used rivastigmine. Regression analysis of the obtained dissolution profiles was performed, and the effects of the pH and the release mechanism were determined. Some substances showed remarkable biological activity and became a subject of interest for further extensive study.<\/jats:p>","DOI":"10.1002\/ardp.202400191","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T16:59:50Z","timestamp":1719593990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New biologically active sulfonamides as potential drugs for Alzheimer's disease"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9004-5430","authenticated-orcid":false,"given":"Marie","family":"Nevyho\u0161t\u011bn\u00e1","sequence":"first","affiliation":[{"name":"Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Komersov\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edr","family":"Pejchal","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160\u00e1rka","family":"\u0160t\u011bp\u00e1nkov\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"\u010cesla","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Matzick","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Mach\u00e1\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology University of Pardubice Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization: Neurological disorders affect millions globally: WHO report. 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