{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:25:05Z","timestamp":1788373505323,"version":"build-2803163510"},"reference-count":81,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Tanacetum nitens<\/jats:italic>\n                    \u00a0(\n                    <jats:sc>Boiss. &amp; No\u00eb<\/jats:sc>\n                    )\u00a0\n                    <jats:sc>Grierson<\/jats:sc>\n                    is an aromatic perennial herb used in Turkish traditional medicine to treat headache, fever, and skin diseases. This study aimed to investigate the chemical composition, antioxidant, enzyme inhibition, and cytotoxic properties of\n                    <jats:italic>T. nitens<\/jats:italic>\n                    aerial parts. Organic solvent extracts were prepared by sequential maceration in hexane, dichloromethane, ethyl acetate, and methanol while aqueous extracts were obtained by maceration or infusion. Nuclear magnetic resonance (NMR) and LC\u2010DAD\u2010MS analysis allowed the identification and quantification of different phytoconstituents including parthenolide, tanacetol B, tatridin B, quinic acid derivatives, \u03b2\u2010sitosterol, and glycoside derivatives of quercetin and luteolin. The type and amount of these phytochemicals recovered by each solvent were variable and significant enough to impact the biological activities of the plant. Methanolic and aqueous extracts displayed the highest scavenging and ions\u2010reducing properties while the dichloromethane and ethyl acetate extracts exerted the best total antioxidant activity and metal chelating power. Results of enzyme inhibition activity showed that the hexane, ethyl acetate, and dichloromethane extracts had comparable anti\u2010acetylcholinesterase activity and the latter extract revealed the highest anti\u2010butyrylcholinesterase activity. The best \u03b1\u2010amylase and \u03b1\u2010glucosidase inhibition activities were obtained from the hexane extract. The dichloromethane and ethyl acetate extracts exhibited the highest cytotoxic effect against the prostate carcinoma DU\u2010145 cells. In conclusion, these findings indicated that\n                    <jats:italic>T. nitens<\/jats:italic>\n                    can be a promising source of biomolecules with potential therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202400194","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:29:24Z","timestamp":1718411364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Combining chemical profiles and biological abilities of different extracts from\n                    <i>Tanacetum nitens<\/i>\n                    \u00a0(\n                    <scp>Boiss. &amp; No\u00eb<\/scp>\n                    )\u00a0\n                    <scp>Grierson<\/scp>\n                    using network pharmacology"],"prefix":"10.1002","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-6953","authenticated-orcid":false,"given":"Stefano","family":"Dall'Acqua","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakina","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Botany, Faculty of Science University of Khartoum Khartoum Sudan"},{"name":"Le Laboratoire Agronomie et Environnement Universit\u00e9 de Lorraine, INRAE, LAE Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Sut","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullahi Ibrahim","family":"Uba","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Istanbul AREL University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathish Kumar M.","family":"Ponniya","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics Pondicherry University Pudhucherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Harran University Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Toprak","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Harran University Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Maruf","family":"Balos","sequence":"additional","affiliation":[{"name":"Sanl\u0131urfa Provincial Directorate of National Education Sanl\u0131urfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alevcan","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Sason Vocational School Batman University Batman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-3604","authenticated-orcid":false,"given":"U\u011fur","family":"\u00c7ak\u0131lc\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Pertek Sakine Gen\u00e7 Vocational School Munzur University Pertek, Tunceli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Faculty, Faculty of Science Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102116"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89437-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13237-022-00405-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1169629"},{"key":"e_1_2_9_6_1","first-page":"170","volume":"5","author":"Bouhlal T.","year":"2017","journal-title":"J. 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