{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T19:25:41Z","timestamp":1781983541976,"version":"3.54.5"},"reference-count":130,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tetrandrine (TET) is a natural bis\u2010benzylisoquinoline alkaloid isolated from <jats:italic>Stephania<\/jats:italic> species with a wide range of biological and pharmacologic activities; it mainly serves as an anti\u2010inflammatory agent or antitumor adjuvant in clinical applications. However, limitations such as prominent hydrophobicity, severe off\u2010target toxicity, and low absorption result in suboptimal therapeutic outcomes preventing its widespread adoption. Nanoparticles have proven to be efficient devices for targeted drug delivery since drug\u2010carrying nanoparticles can be passively transported to the tumor site by the enhanced permeability and retention (EPR) effects, thus securing a niche in cancer therapies. Great progress has been made in nanocarrier construction for TET delivery due to their outstanding advantages such as increased water\u2010solubility, improved biodistribution and blood circulation, reduced off\u2010target irritation, and combinational therapy. Herein, we systematically reviewed the latest advancements in TET\u2010loaded nanoparticles and their respective features with the expectation of\u00a0providing\u00a0perspective and guidelines for future research and potential applications of TET.<\/jats:p>","DOI":"10.1002\/ardp.202400274","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T21:35:07Z","timestamp":1718919307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Advances in nano\u2010preparations for improving tetrandrine solubility and bioavailability"],"prefix":"10.1002","volume":"357","author":[{"given":"Jie","family":"Ling","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Wu","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuening","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujun","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Ge","sequence":"additional","affiliation":[{"name":"School of Marxism Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Liu","sequence":"additional","affiliation":[{"name":"Hematology Department The General Hospital of the Western Theater Command PLA Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Center The First Affiliated Hospital of Shantou University Medical College Shantou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-8682","authenticated-orcid":false,"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2021.01.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8589121"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01452-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111700"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176459"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026623666230106144509"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2021.35.s1.01870"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110139"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8315"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.01.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114635"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095280"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.am2019-3910"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x23500222"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.120.000050"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2034256"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.04.029"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.116"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13339"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.05.023"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814029-1.00005-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.115823"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.15212\/AMM-2023-0038"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2018.06.005"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12121156"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113870"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-021-01276-x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x22500860"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.05.018"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.14.159"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202310876"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112737"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08982104.2023.2268710"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2015.02.002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8360"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/08982104.2017.1408649"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.09.024"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/08982104.2020.1748647"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103492"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126858"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.18231\/j.jpbs.2022.014"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/161943"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.06.022"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202100109"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9665-3"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2013.795582"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.04.026"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S50557"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.05.004"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-016-1471-0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.09.010"},{"issue":"10","key":"e_1_2_9_53_1","first-page":"2482","volume":"2","author":"Bhatt P.","year":"2011","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.008"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.partic.2021.05.009"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6763057"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.800283"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030831"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215346"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201024666230523114350"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b07961"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.31069\/japsr.v4i3.2"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10071403"},{"key":"e_1_2_9_64_1","doi-asserted-by":"crossref","unstructured":"C.Vasile inPolymeric Nanomaterials in Nanotherapeutics(Ed: C. Vasile) Elsevier 2019 Ch. 1.https:\/\/doi.org\/10.1016\/B978-0-12-813932-5.00001-7","DOI":"10.1016\/B978-0-12-813932-5.00001-7"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1054\/drup.2000.0119"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024172"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.09.008"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.06.007"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2010.04.016"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S55541"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2016.2293"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2016.1156175"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.12.006"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-016-1535-5"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.134196"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.01.011"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1573861"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.02.001"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2058648"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0494-y"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00310"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.5.609"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S34886"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp2002736"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00381"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46057"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17363"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186x.2020.1777419"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26546"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp100277h"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S85587"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120807"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-014-9637-0"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b01908"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.05.003"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.110842"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLK.2008.n.013"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103572"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123625"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081636"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-020-01056-z"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00705"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s2714"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.044"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2019.1631403"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.05.010"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102486"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2017.1399"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074589"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S326614"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809795105"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01705"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0ra01458c"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201902634"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2016.02.005"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-007-0416-9"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0779-2"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.107069"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.03.002"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105377"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2017.06.008"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.05.021"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814033-8.00008-4"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1111991"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116183"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.202000150"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.15212\/bioi-2021-0016"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00017"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2020.122036"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.114083"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202000673"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202400274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:19:17Z","timestamp":1736835557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.202400274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":130,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/ardp.202400274"],"URL":"https:\/\/doi.org\/10.1002\/ardp.202400274","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]},"assertion":[{"value":"2024-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2400274"}}