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To obtain subtype\u2010selective and potent HDAC inhibitors, we used the aminobenzamide scaffold as the zinc\u2010binding group and prepared new derivatives with a pyrazole ring as the linking group. The synthesized compounds were analyzed in vitro using an enzymatic assay against HDAC1, \u22122, and \u22123. Compounds <jats:bold>12b<\/jats:bold>, <jats:bold>15b<\/jats:bold>, and <jats:bold>15i<\/jats:bold> were found to be potent HDAC1 inhibitors, also in comparison to the reference compounds entinostat and tacedinaline, with IC<jats:sub>50<\/jats:sub> values of 0.93, 0.22, and 0.68\u2009\u03bcM, respectively. The best compounds were measured for their cellular effect and target engagement in acute myeloid leukemia (AML) cells. In addition, we studied the interaction of the compounds with HDAC subtypes using docking and molecular dynamic simulations. 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