{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:51:28Z","timestamp":1793731888809,"version":"4.6.1"},"reference-count":341,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The NOD\u2010like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome is a key component of the innate immune system that triggers inflammation and pyroptosis and contributes to the development of several diseases. Therefore, blocking the activation of the NLRP3 inflammasome has therapeutic potential for the treatment of these diseases. MCC950, a selective small molecule inhibitor, has emerged as a promising candidate for blocking NLRP3 inflammasome activation. Ongoing research is focused on elucidating the specific targets of MCC950 as well as assessfing its metabolism and safety profile. This review discusses the diseases that have been studied in relation to MCC950, with a focus on stroke, Alzheimer's disease, liver injury, atherosclerosis, diabetes mellitus, and sepsis, using bibliometric analysis. It then summarizes the potential pharmacological targets of MCC950 and discusses its toxicity. Furthermore, it traces the progression from preclinical to clinical research for the treatment of these diseases. Overall, this review provides a solid foundation for the clinical therapeutic potential of MCC950 and offers insights for future research and therapeutic approaches.<\/jats:p>","DOI":"10.1002\/ardp.202400459","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T02:31:24Z","timestamp":1724466684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["MCC950 as a promising candidate for blocking NLRP3 inflammasome activation: A review of preclinical research and future directions"],"prefix":"10.1002","volume":"357","author":[{"given":"Yujia","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Integrative Medicine Tianjin University of Traditional Chinese Medicine, Jinghai Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine Tianjin University of Traditional Chinese Medicine, Jinghai Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine Tianjin University of Traditional Chinese Medicine, Jinghai Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine Tianjin University of Traditional Chinese Medicine, Jinghai Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayuan","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine Tianjin University of Traditional Chinese Medicine, Jinghai Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine Tianjin University of Traditional Chinese Medicine, Jinghai Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-3376","authenticated-orcid":false,"given":"Xijuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine Tianjin University of Traditional Chinese Medicine, Jinghai Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8954-9494","authenticated-orcid":false,"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicial Technology Tianjin University of Traditional Chinese Medicine Tianjin Jinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.139"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004832"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aau0615"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0308-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12286"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.09.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.11.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112379"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.076"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201602089"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.10.004"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.016"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3333"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111195"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812744115"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16959"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.797126"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211596200"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00227-x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1636"},{"issue":"1","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-3565(24)29317-4","volume":"299","author":"Perregaux D. G.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3806"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.08.089"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26775-w"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.02.011"},{"issue":"4","key":"e_1_2_11_27_1","first-page":"45","volume":"20","author":"Gumucio D. L.","year":"2002","journal-title":"Clin. Exp. Rheumatol."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0277-7"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2018.1511513"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-016-2160-x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12563"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000492"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308413"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.326"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.03.010"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.04.017"},{"issue":"4","key":"e_1_2_11_37_1","first-page":"4787","volume":"8","author":"Tong Y.","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.2.271"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2013.09.004"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-2938-1"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527313666141023094720"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.242"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029071"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.12.009"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2023.05.021"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153849"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24350-x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137164"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02674-w"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.192535"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0221-1"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008861"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04379-z"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040762"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00132"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-015-0184-5"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-440057"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117638"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15732"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106001"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5344"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02871-1"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.05.016"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.628908"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-023-10520-6"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007454"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0976-8"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70104-7"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009357"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1653"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3295"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018904"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104468"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30668-7"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0690-x"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02207-x"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.573454"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-022-01064-x"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108967"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02765-2"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001489"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjac077"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.03.002"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153251"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-019-02935-w"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02819-5"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.06.009"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.04.031"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.714943"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2021.1922402"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020189"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.137032"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70176-0"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00914-4"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-021-00791-3"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5539-y"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/bs10080128"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.319951"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c07859"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.235112"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19786-7"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1412-9"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0483-3"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439214"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.02.010"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100002389"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00936-3"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.09.003"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81705-7"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-02022-w"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11729"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1107"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.12.014"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.02.046"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-01957-y"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14945"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0556-6"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-072116-031153"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.2505"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1319-x"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-020-05916-6"},{"key":"e_1_2_11_122_1","first-page":"1","volume":"2021","author":"Li K.","year":"2021","journal-title":"Neural. Plast."},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5715"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.02.016"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.11.006"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01056-9"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.816640"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.925435"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.10.011"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1313-3"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02791-0"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.02.973"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-023-00387-5"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03072-x"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.11.031"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1974164676"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj192"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489966"},{"issue":"1","key":"e_1_2_11_139_1","first-page":"1","volume":"10","author":"Xu T.","year":"2018","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092732"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.01.022"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.752223"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.03.006"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001259"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01109-y"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01128-x"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1109058"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.004"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.05.012"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03576.x"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e328352812c"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1981.tb08716.x"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092931"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.02.002"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.11.009"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-018-0020-3"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00647-1"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1015846"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.682823"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107352"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i16.2912"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00146.2014"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2016.08.006"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00427.2019"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.50919"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7121091"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13030221"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111867"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24061040"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.839364"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081275"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-14700-0"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1080\/10937400701597766"},{"issue":"39","key":"e_1_2_11_174_1","first-page":"653","volume":"114","author":"Klotz K.","year":"2017","journal-title":"Dtsch. Arztebl. Int."},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.125382"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2017.04.016"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.10.002"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59710-z"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110229"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.112"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-022-01024-1"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101400"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01571-3"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.756299"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010331"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123294"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115457"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2022.102056"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13811"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100463"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.031"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1253227"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25769"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31494"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.02.016"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32226"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06592.x"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.029"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02364-z"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.044"},{"key":"e_1_2_11_201_1","first-page":"1","volume":"2019","author":"Zhang L.","year":"2019","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004604"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10050208"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.312215"},{"key":"e_1_2_11_205_1","first-page":"1","volume":"2020","author":"Lin K.","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.08.004"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03542-0"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00309"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.02.007"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00943-0"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.716332"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113477"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.111.2877.166"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00130"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8030080"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-01944-8"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002767"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006347"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18297-3"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01289-8"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315939"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00629-x"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-023-00330-5"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3258"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.08.002"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0169-2"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108668"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116184"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.18"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98437-3"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309575"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0357"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.11.064"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306361"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046672"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.599415"},{"key":"e_1_2_11_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2019.106579"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.08.017"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab337"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1274-6"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100695RR"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116304"},{"key":"e_1_2_11_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00981-y"},{"key":"e_1_2_11_244_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1013162"},{"key":"e_1_2_11_245_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.870465"},{"key":"e_1_2_11_246_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.750135"},{"key":"e_1_2_11_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30362-5"},{"key":"e_1_2_11_248_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.63219"},{"key":"e_1_2_11_249_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513509112"},{"key":"e_1_2_11_250_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7313"},{"key":"e_1_2_11_251_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19040975"},{"key":"e_1_2_11_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2022.114068"},{"key":"e_1_2_11_253_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1114620"},{"key":"e_1_2_11_254_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmz032"},{"key":"e_1_2_11_255_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.02.001"},{"key":"e_1_2_11_256_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.12958"},{"key":"e_1_2_11_257_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0922-9"},{"key":"e_1_2_11_258_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302439"},{"key":"e_1_2_11_259_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413573"},{"key":"e_1_2_11_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.02.012"},{"key":"e_1_2_11_261_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121595"},{"key":"e_1_2_11_262_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310221"},{"key":"e_1_2_11_263_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01182-6"},{"key":"e_1_2_11_264_1","first-page":"1","volume":"2018","author":"Hong P.","year":"2018","journal-title":"Neural. Plast."},{"key":"e_1_2_11_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.01.035"},{"key":"e_1_2_11_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.01.030"},{"key":"e_1_2_11_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.01.001"},{"key":"e_1_2_11_268_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00025"},{"key":"e_1_2_11_269_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030522"},{"key":"e_1_2_11_270_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0130"},{"key":"e_1_2_11_271_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.308"},{"key":"e_1_2_11_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2021.104265"},{"key":"e_1_2_11_273_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.734360"},{"key":"e_1_2_11_274_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.64.3.16"},{"key":"e_1_2_11_275_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.932205"},{"key":"e_1_2_11_276_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.2902"},{"key":"e_1_2_11_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154748"},{"key":"e_1_2_11_278_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/7423661"},{"key":"e_1_2_11_279_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.790937"},{"key":"e_1_2_11_280_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.667644"},{"key":"e_1_2_11_281_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13182"},{"key":"e_1_2_11_282_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2257-y"},{"key":"e_1_2_11_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.07.027"},{"key":"e_1_2_11_284_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S199802"},{"key":"e_1_2_11_285_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210865"},{"key":"e_1_2_11_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.08.020"},{"key":"e_1_2_11_287_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02669-7"},{"key":"e_1_2_11_288_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000200"},{"key":"e_1_2_11_289_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-1038"},{"key":"e_1_2_11_290_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2023.110796"},{"key":"e_1_2_11_291_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153826"},{"key":"e_1_2_11_292_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.106"},{"key":"e_1_2_11_293_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076309"},{"key":"e_1_2_11_294_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-1218"},{"key":"e_1_2_11_295_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164117698917"},{"key":"e_1_2_11_296_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.748183"},{"key":"e_1_2_11_297_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_11_298_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14073"},{"key":"e_1_2_11_299_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344063"},{"key":"e_1_2_11_300_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601745"},{"key":"e_1_2_11_301_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.952337"},{"key":"e_1_2_11_302_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155102"},{"key":"e_1_2_11_303_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1239678"},{"key":"e_1_2_11_304_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abm1803"},{"key":"e_1_2_11_305_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01232-x"},{"key":"e_1_2_11_306_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107388"},{"key":"e_1_2_11_307_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02089-9"},{"key":"e_1_2_11_308_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02598-5"},{"key":"e_1_2_11_309_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-018-0894-4"},{"key":"e_1_2_11_310_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-020-01347-9"},{"key":"e_1_2_11_311_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001378"},{"key":"e_1_2_11_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.10.031"},{"key":"e_1_2_11_313_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2033381"},{"key":"e_1_2_11_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108106"},{"key":"e_1_2_11_315_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-023-01705-3"},{"key":"e_1_2_11_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2020.12.041"},{"key":"e_1_2_11_317_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.032"},{"key":"e_1_2_11_318_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700719"},{"key":"e_1_2_11_319_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13006"},{"key":"e_1_2_11_320_1","first-page":"1","volume":"2021","author":"Wang Y.","year":"2021","journal-title":"BioMed Res. Int."},{"key":"e_1_2_11_321_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204189"},{"key":"e_1_2_11_322_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14109"},{"key":"e_1_2_11_323_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000067"},{"key":"e_1_2_11_324_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234039"},{"key":"e_1_2_11_325_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00644"},{"key":"e_1_2_11_326_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2014.08.010"},{"key":"e_1_2_11_327_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2015.00079"},{"key":"e_1_2_11_328_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007795"},{"key":"e_1_2_11_329_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.97"},{"key":"e_1_2_11_330_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20204974"},{"key":"e_1_2_11_331_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02406"},{"key":"e_1_2_11_332_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i8.2533"},{"key":"e_1_2_11_333_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820282116"},{"key":"e_1_2_11_334_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-01098-8"},{"key":"e_1_2_11_335_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175091"},{"key":"e_1_2_11_336_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108595"},{"key":"e_1_2_11_337_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000171"},{"key":"e_1_2_11_338_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04349-5"},{"key":"e_1_2_11_339_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.915969"},{"key":"e_1_2_11_340_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_2_11_341_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.108053"},{"key":"e_1_2_11_342_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy310"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202400459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T13:22:03Z","timestamp":1755609723000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.202400459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":341,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ardp.202400459"],"URL":"https:\/\/doi.org\/10.1002\/ardp.202400459","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"2024-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2400459"}}