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The selective inhibition of CA IX and CA XII isoforms can result in the development of better cancer treatment strategies. The tail approach based on coumarin derivatives was known for selective inhibition of isoforms IX and XII. This study explores the potential of coumarin derivatives (<jats:bold>7a\u2013k<\/jats:bold>, <jats:bold>8a\u2013s<\/jats:bold> and <jats:bold>9a\u2013g<\/jats:bold>) as selective hCA IX and hCA XII inhibitors. The synthesised derivatives exhibited potent and selective inhibition towards hCA IX and XII, with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 0.58\u20123.33\u2009\u00b5M and 0.48\u20122.59\u2009\u00b5M, respectively. The oxime ether derivative <jats:bold>7d<\/jats:bold> was found to be the most potent one against hCA IX, with a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 0.58\u2009\u00b5M, and phenyl hydrazine derivative <jats:bold>8a<\/jats:bold>, with a <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value of 0.48\u2009\u00b5M against hCA XII, was the most potent one among the synthesised molecules. The potent isoform\u2010specific carbonic anhydrase IX and XII inhibition suggests that <jats:bold>7d<\/jats:bold> and <jats:bold>8a<\/jats:bold> can be taken further towards the development of potent anticancer agents.<\/jats:p>","DOI":"10.1002\/ardp.202400482","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T09:14:06Z","timestamp":1734426846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New 7\u2010hydroxycoumarin acetamide derivatives as human carbonic anhydrase IX and XII inhibitors: Design, synthesis, biological evaluation and molecular docking studies"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9828-1124","authenticated-orcid":false,"given":"Sarvan","family":"Maddipatla","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER), Balanagar 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