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This study aimed to enhance the efficacy of topical application of fluticasone propionate (FP) using a eucalyptus oil\u2010based nanoemulsion, an oil possessing anti\u2010inflammatory activity and extracted from the leaves, fruits, and buds of <jats:italic>Eucalyptus globulus<\/jats:italic> or <jats:italic>Eucalyptus maidenii<\/jats:italic>, to improve the skin deposition of FP and aid its anti\u2010inflammatory effect. Box\u2010Behnken design was employed to optimize NE formulations, which were characterized for globule size, zeta potential, polydispersity index, rheological behavior, microscopic morphology, ex vivo skin permeation\/deposition, and in vivo efficacy using imiquimod\u2010induced psoriatic lesions. The optimized formulation depicted a droplet size of 188\u2009\u00b1\u200922.4\u2009nm, a zeta potential of \u221217.63\u2009\u00b1\u20091.66\u2009mV, and a viscosity of 204.9\u2009mPa\u2009s. In addition to the increased FP retention in different skin layers caused by the NE and the reduced PASI score compared to the marketed cream, the levels of inflammatory cytokines IL\u20101\u03b1, IL\u20106, IL17a were markedly lowered, indicating the improved anti\u2010psoriatic curable efficacy of the optimized formulation in comparison to the FP\u2010marketed product.<\/jats:p>","DOI":"10.1002\/ardp.202400557","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T05:46:40Z","timestamp":1729835200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Eucalyptus oil nanoemulsion for enhanced skin deposition of fluticasone propionate in psoriatic plaques: A combinatorial anti\u2010inflammatory effect to suppress implicated cytokines"],"prefix":"10.1002","volume":"358","author":[{"given":"Mohamed","family":"Ashraf","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy Egyptian Russian University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-6340","authenticated-orcid":false,"given":"Hossam S.","family":"El\u2010Sawy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy Egyptian Russian University Cairo Egypt"},{"name":"Department of Pharmacy Al\u2010Kut University College Kut Wasit Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-140X","authenticated-orcid":false,"given":"Ghada M.","family":"El Zaafarany","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-1248","authenticated-orcid":false,"given":"Mona M. 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