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The current investigation aims to develop a novel, eco\u2010friendly, and sustainable reverse\u2010phase high\u2010performance liquid chromatography (RP\u2010HPLC) method for the simultaneous quantification of capecitabine and celecoxib co\u2010encapsulated in liposomes. The method reported herein uses a C<jats:sub>18<\/jats:sub> column (4.6\u2009\u00d7\u2009250\u2009mm<jats:sup>2<\/jats:sup>, 5\u2009\u03bcm) and a mobile phase consisting of water, and acetonitrile\/methanol in a ratio of 60:40, containing 0.1% formic acid in both the phases. The flow rate is maintained at 1\u2009mL\/min, with an injection volume of 10\u2009\u03bcL in the gradient mode. Detection is set at <jats:italic>\u03bb<\/jats:italic><jats:sub>max<\/jats:sub>\u2009=\u2009240\u2009nm for capecitabine and 252\u2009nm for celecoxib. The developed liposomes are mono\u2010disperse with a surface potential of \u22126.93\u2009mV. The average size of the liposomes is 142\u2009nm. The percentage entrapment efficiency for capecitabine is 52.39\u2009\u00b1\u20090.94%, and for celecoxib, it is 77.13\u2009\u00b1\u20090.74%. The Analytical Greenness Metric of 0.61 and Analytical Eco\u2010Scale Score of 75 signify the greenness of the developed method. Also, the Red\u2010Green\u2010Blue model shows excellent whiteness, with a score of 83.2. Thus, the developed method offers a reliable, accurate, precise, buffer\u2010free, and environment\u2010friendly RP\u2010HPLC approach for the simultaneous analysis of capecitabine and celecoxib co\u2010encapsulated in liposomes.<\/jats:p>","DOI":"10.1002\/ardp.202400632","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:15:42Z","timestamp":1727676942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A sustainable RP\u2010HPLC method for concurrent estimation of capecitabine and celecoxib in liposomal formulation: Greenness and whiteness appraisal"],"prefix":"10.1002","volume":"357","author":[{"given":"Rushikesh Sanjay","family":"Shewale","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics National Institute of Pharmaceutical Education and Research\u2010Ahmedabad (NIPER\u2010A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers Gandhinagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam Sudhakar","family":"Gomte","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics National Institute of Pharmaceutical Education and Research\u2010Ahmedabad (NIPER\u2010A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers Gandhinagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-5337","authenticated-orcid":false,"given":"Aakanchha","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics National Institute of Pharmaceutical Education and Research\u2010Ahmedabad (NIPER\u2010A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers Gandhinagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2022.2161780"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573394713666170622104347"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2022.2153862"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.10.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.07.022"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1AY01919H"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.1202"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-112"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(07)70274-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0436"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh322"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2023.2279792"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-41842-7_5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2992"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-020-01042-5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-360X.2016.00400.5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639040500216378"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.10.048"},{"key":"e_1_2_8_22_1","first-page":"237","volume":"2","author":"Elsonbaty A.","year":"2023","journal-title":"ERURJ"},{"key":"e_1_2_8_23_1","first-page":"492","volume":"3","author":"Rao M. 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