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Curcumin, a polyphenol derived from <jats:italic>Curcuma longa<\/jats:italic> L., is one of the most extensively studied natural compounds with the potential as an effective P\u2010gp inhibitor. Despite its promising attributes, the clinical application of P\u2010gp inhibitors is complicated by P\u2010gp's presence in healthy cells, such as those in the intestinal barrier and blood\u2013brain barrier, which can lead to increased toxicity. To address these challenges, we developed a novel multifunctional nanomaterial by covalently bonding halloysite nanotubes (HNTs) with hectorite (Ht) and loading it with curcumin and doxorubicin. The efficacy of the co\u2010delivery of curcumin and doxorubicin by HNTs\u2010Ht nanomaterial was evaluated by cytotoxicity assays on MCF\u20107R cells, both in two\u2010dimensional (2D) and in three\u2010dimensional (3D) models. The obtained data show that curcumin causes increased doxorubicin accumulation by acting as a substrate for P\u2010gp transport and as a stimulator of the adenosine triphosphate (ATP)\u2010dependent drug efflux transporter on a doxorubicin\u2010resistant breast cancer cell line. The results suggest that the HNTs\u2010Ht nanomaterial could provide a promising approach to improve chemotherapy effectiveness by overcoming MDR and enhancing treatment outcomes.<\/jats:p>","DOI":"10.1002\/ardp.202400702","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T04:34:26Z","timestamp":1735274066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Curcumin and doxorubicin encapsulated in biocompatible clay\u2010based nanomaterial: A strategy to overcome multidrug resistance"],"prefix":"10.1002","volume":"358","author":[{"given":"Paola","family":"Poma","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF) Universit\u00e0 di Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Massaro","sequence":"additional","affiliation":[{"name":"Dipartimento 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