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Conjugates demonstrated high acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition (IC<jats:sub>50<\/jats:sub>: AChE, 0.265\u22124.24\u2009\u03bcM; BChE, 0.01\u22120.64\u2009\u03bcM) but poor activity against off\u2010target carboxylesterase (CES). Specifically, conjugates with a (CH<jats:sub>2<\/jats:sub>)<jats:sub>8<\/jats:sub> spacer showed the highest AChE and BChE inhibition: 3\u201316 times more effective than amiridine. Salicylamides <jats:bold>7b<\/jats:bold> and <jats:bold>7c<\/jats:bold> had the maximum BChE\/AChE selectivity ratios: 193 and 138, respectively. Conjugates were mixed\u2010type reversible inhibitors of both cholinesterases and displaced propidium from the AChE peripheral anionic site (PAS) at the level of donepezil. All conjugates inhibited A\u03b2<jats:sub>42<\/jats:sub> self\u2010aggregation in the thioflavin test; inhibition increased with spacer elongation, being greatest for (CH<jats:sub>2<\/jats:sub>)<jats:sub>8<\/jats:sub>. The results agreed with molecular docking to AChE, BChE, and A\u03b2<jats:sub>42<\/jats:sub>. Conjugates exhibited high 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) (ABTS)<jats:sup>\u2022+<\/jats:sup>\u2010scavenging activity comparable to the standard antioxidant Trolox, and they showed the ability to bind Cu<jats:sup>2+<\/jats:sup>, Fe<jats:sup>2+<\/jats:sup>, and Zn<jats:sup>2+<\/jats:sup>. Conjugates had favorable predicted intestinal absorption and blood\u2013brain barrier permeability. Altogether, the results indicate that the new conjugates possess potential for further development as multifunctional anti\u2010AD drug candidates.<\/jats:p>","DOI":"10.1002\/ardp.202400819","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T09:16:09Z","timestamp":1734426969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Conjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-6906","authenticated-orcid":false,"given":"Galina F.","family":"Makhaeva","sequence":"first","affiliation":[{"name":"Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry Russian Academy of Sciences Chernogolovka 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