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The compound <jats:bold>1<\/jats:bold>, herein reported for the first time, salvianolic acid P <jats:bold>2<\/jats:bold>, clinopodic acid I <jats:bold>3<\/jats:bold>, and clinopodic acid O <jats:bold>4<\/jats:bold> were all profiled in vitro on a panel of human (h) expressed carbonic anhydrases (CAs; EC 4.2.1.1) and preferential inhibition for the tumor\u2010associated human carbonic anhydrase (hCA) IX and hCA XII over the constitutively expressed hCA I and hCA II isoforms was observed. X\u2010ray crystallography allowed us to assess the binding mode of salvianolic acid P <jats:bold>2<\/jats:bold> to hCA II. The compounds exhibited significant cytotoxic effects on the human triple\u2010negative breast cancer cell line MDA\u2010MB\u2010231, suggesting that this class of depsides are promising molecules for future investigation.<\/jats:p>","DOI":"10.1002\/ardp.202400823","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T07:24:19Z","timestamp":1734938659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Depsides from <i>Origanum dictamnus<\/i> and <i>Satureja pilosa<\/i> as selective inhibitors of carbonic anhydrases: Isolation, structure elucidation, X\u2010ray crystallography"],"prefix":"10.1002","volume":"358","author":[{"given":"Charikleia","family":"Paloukopoulou","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacognosy, Department of Pharmacy Aristotle University of Thessaloniki Thessaloniki 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