{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:31:54Z","timestamp":1792420314077,"version":"4.5.0"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer, characterized by uncontrolled growth and spread of abnormal cells potentially influencing almost all tissues in the body, is one of the most devastating and lethal diseases throughout the world. Chemotherapy is one of the principal approaches for cancer treatment, but multidrug resistance and severe side effects represent the main barriers to the success of therapy, creating a vital need to develop novel chemotherapeutic agents. The 1,2,3\u2010triazole moiety can be conveniently constructed by \u201cclick chemistry\u201d and could exert diverse noncovalent interactions with various enzymes in cancer cells. Hence, 1,2,3\u2010triazole is one of the most fascinating anticancer pharmacophores. Moreover, 1,2,3\u2010triazole could also serve as a powerful ligation tool for the complex molecular architectures to increase the anticancer efficacy of lead molecules. Notably, 1,2,3\u2010triazole\u2010containing hybrids with intriguing structural variations could target different biological components in cancer cells simultaneously, highlighting their potential in the treatment and eradication of cancer. This review outlines the current landscape of 1,2,3\u2010triazole\u2010(fused) six\u2010membered nitrogen\u2010containing heteroaromatic ring hybrids, inclusive of 1,2,3\u2010triazole\u2010quinazolines, 1,2,3\u2010triazole\u2010quinazolinones, 1,2,3\u2010triazole\u2010quinolines, 1,2,3\u2010triazole\u2010quinolones, 1,2,3\u2010triazole\u2010pyridines, and 1,2,3\u2010triazole\u2010pyrimidines, with anticancer therapeutic potential, and explores their mechanisms of action, critical aspects of design as well as structure\u2013activity relationships (SARs), covering articles published from 2021 to the present, to pave the way for the development of innovative and efficient therapeutic interventions for cancer therapy.<\/jats:p>","DOI":"10.1002\/ardp.202400873","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:29:58Z","timestamp":1735630198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The current landscape of 1,2,3\u2010triazole\u2010(fused) six\u2010membered nitrogen\u2010containing heteroaromatic ring hybrids with anticancer therapeutic potential"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-1392","authenticated-orcid":false,"given":"Zhi","family":"Xu","sequence":"first","affiliation":[{"name":"Huanghuai University Industry Innovation &amp; Research and Development Institute Huanghuai University  Zhumadian Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongqiang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Huanghuai University  Zhumadian Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhumadian City Product Inspection and Testing Center  Zhumadian Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Huanghuai University  Zhumadian Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.10.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2023.K.0026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-19-1158"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00968D"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_7_1","unstructured":"International Agency for Research on Cancer. 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