{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:42Z","timestamp":1786977102110,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obesity is a global health crisis linked to chronic diseases like cardiovascular disease and type 2 diabetes. Its prevalence, even in low\u2010income countries, highlights the failure of traditional interventions. Safer pharmacological treatments are urgently needed, as many existing antiobesity drugs have been withdrawn due to severe side effects, leaving a critical therapeutic gap. A promising target in this context is human carbonic anhydrase V (\n                    <jats:italic>h<\/jats:italic>\n                    CA V), a mitochondrial enzyme that plays a key role in glucose homeostasis. Inhibiting\n                    <jats:italic>h<\/jats:italic>\n                    CA V has been shown to reduce lipogenesis and improve metabolic conditions. Natural plant extracts, such as silymarin from milk thistle, have demonstrated potential in managing obesity\u2010related metabolic syndromes by lowering triglycerides, reducing cholesterol levels, and improving liver function. Our computational studies have identified active compounds in silymarin that effectively inhibit\n                    <jats:italic>h<\/jats:italic>\n                    CA V, shedding light on a potential mechanism for its antiobesity effects. Building on these findings, our research further reveals that these compounds also inhibit carbonic anhydrase VII (\n                    <jats:italic>h<\/jats:italic>\n                    CA VII), enhancing their therapeutic potential. This dual inhibitory action addresses both metabolic dysregulation and oxidative stress. Notably, the antioxidant properties of\n                    <jats:italic>h<\/jats:italic>\n                    CA VII provide additional protection against obesity\u2010related complications by mitigating oxidative stress, a key contributor to the development of metabolic syndrome.\n                  <\/jats:p>","DOI":"10.1002\/ardp.202400966","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T13:54:29Z","timestamp":1742824469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dual inhibition of carbonic anhydrases VA and VII by silychristin and isosilybin A from\n                    <i>Silybum marianum<\/i>\n                    : A potential antiobesity strategy"],"prefix":"10.1002","volume":"358","author":[{"given":"Emanuele Liborio","family":"Citriniti","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze della Salute Universit\u00e0 \u201cMagna Gr\u00e6cia\u201d di Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0680-7097","authenticated-orcid":false,"given":"Roberta","family":"Rocca","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute Universit\u00e0 \u201cMagna Gr\u00e6cia\u201d di Catanzaro Catanzaro Italy"},{"name":"Net4Science S.r.l. 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