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Four new analogs of ANG 1\u20107 with general structures of Asp\u2010Arg\u2010Val\u2010Tyr\u2010Ile\u2010His\u2010Xxx\u2010NH<jats:sub>2<\/jats:sub>, where Xxx is 1\u2010aminocyclopentanecarboxylic acid (Ac5c), 1\u2010aminocyclohexane carboxylic acid (Ac6c), and (2S,4S)\u20104\u2010amino\u2010pyrrolidine\u20102\u2010carboxylic acid, were synthesized and characterized by electrochemical, spectral, DFT calculational, and behavioral methods. The presence of a cis\u2010oriented primary amino group at the molecule's C\u2010terminus is coupled with the structural rigidity of the pyrrolidine Pro ring in the peptide molecule ANG\u2010P1. While in ANG\u2010P2, the cis\u2010oriented primary amino group is connected to the peptide motif by means of the amino acid His leading to the formation of a proline\/GABA cis\u2010chimera. The partition coefficient values suggest better lipophilicity of the compounds ANG\u2010P1 and ANG\u2010P2 related to easier passage through the target membranes. The correlation coefficient between the theoretically predicted and experimentally determined logP values is 0.991. The ANG\u2010P1 analog has features comparable to ANG 1\u20107, but the peptides ANG\u2010P2, ANG\u2010C5, and ANG\u2010C6 exhibit distinct effects, particularly on anxiety\u2010like behavior, according to a comparison of the novel analogs with the precursor peptide. Regardless of how they affect exploration in the open field test, they induce anxiogenic behavior in the elevated plus maze test. The ANG\u2010C5 analog differs from the other analogs because it is unable to create antinociception, despite the fact that ANG 1\u20107 and its analogs generated notable antinociception.<\/jats:p>","DOI":"10.1002\/ardp.202500093","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:39:16Z","timestamp":1742197156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and analytical profile of new synthetic analogs of angiotensin 1\u20107, the main balancing peptide of the renin\u2013angiotensin system"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8050-0149","authenticated-orcid":false,"given":"Petar","family":"Todorov","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry University of Chemical Technology and Metallurgy  Sofia 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