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The structural features of ABL1 include a distinct N\u2010terminal cap region, a C\u2010terminal tail, a bilobed kinase, SH2, and SH3 domains. These domains enable its engagement in several signaling cascades and dynamic control. The pathophysiology of chronic myeloid leukemia (CML) is mainly driven by the BCR\u2010ABL1 oncoprotein, arising from dysregulation of ABL1 kinase, namely through its fusion to the breakpoint cluster region (BCR) gene. ABL1 is a crucial target in the treatment of CML as the BCR\u2010ABL1 fusion causes uncontrolled cellular proliferation and resistance to apoptosis. Tyrosine kinase inhibitors (TKIs) targeting the ABL1 tyrosine kinase are playing a critical role in the treatment of CML through the inhibition of persistently activated signaling pathways mediated by the BCR\u2010ABL1 fusion protein. The article examines the structural characteristics of ABL1, how they relate to CML, and the interactions between ABL1 and the current FDA\u2010approved TKIs, emphasizing the kinase's critical function in carcinogenesis and its possible target status for tyrosine kinase inhibitors.<\/jats:p>","DOI":"10.1002\/ardp.70005","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:26:10Z","timestamp":1746836770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Structure and Dynamics of the ABL1 Tyrosine Kinase and Its Important Role in Chronic Myeloid Leukemia"],"prefix":"10.1002","volume":"358","author":[{"given":"Ayca","family":"Irgit","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics Koc University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyhan","family":"Kam\u0131s","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Koc University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-9711","authenticated-orcid":false,"given":"Belgin","family":"Sever","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University Eskisehir Turkey"},{"name":"Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5698-1109","authenticated-orcid":false,"given":"Ama\u00e7 Fatih","family":"Tuyun","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Istanbul University, Fatih \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences Kumamoto University Kumamoto Japan"},{"name":"Department of Drug Discovery Science Farm Ltd. 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