{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:46:56Z","timestamp":1774874816904,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The root of\n                    <jats:italic>Platycodon grandiflorum<\/jats:italic>\n                    has long been used as a vegetable and traditional medicine. Although the antibacterial activity of the plant's lipophilic (hexanes and dichloromethane) fractions has been reported, the specific antibacterial compounds have not been identified. In this study, chemical analysis of the lipophilic fractions of\n                    <jats:italic>P. grandiflorum<\/jats:italic>\n                    extracts led to the discovery of five new polyacetylenes (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    ) and nine known compounds (\n                    <jats:bold>6<\/jats:bold>\n                    \u2013\n                    <jats:bold>14<\/jats:bold>\n                    ). Their structures were elucidated and confirmed based on 1D and 2D NMR data together with mass spectra. In particular, the relative and absolute configurations of\n                    <jats:bold>1<\/jats:bold>\n                    were elucidated by coupling constants, NOESY and\n                    <jats:italic>J<\/jats:italic>\n                    \u2010based configurational analysis in combination with Mosher's method. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    demonstrated strong antifungal activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . Additionally, compound\n                    <jats:bold>1<\/jats:bold>\n                    significantly inhibited quorum sensing in\n                    <jats:italic>Chromobacterium violaceum<\/jats:italic>\n                    , a commonly used biosensor strain. Compounds\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>14<\/jats:bold>\n                    also exhibited mild inhibitory activity. Compounds\n                    <jats:bold>8<\/jats:bold>\n                    and\n                    <jats:bold>12<\/jats:bold>\n                    \u2013\n                    <jats:bold>14<\/jats:bold>\n                    exhibited potent antibacterial activity against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Kocuria rhizophila<\/jats:italic>\n                    , and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , as well as antifungal activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . These compounds may be responsible of the antimicrobial activity of\n                    <jats:italic>P. grandiflorum<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/ardp.70043","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:27:58Z","timestamp":1752074878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Structure Characterization and Antibacterial, Antifungal, and Antiquorum\u2010Sensing Activity of New Metabolites From the Lipophilic Fractions of\n                    <i>Platycodon grandiflorum<\/i>\n                    Root"],"prefix":"10.1002","volume":"358","author":[{"given":"Hyukbean","family":"Kwon","sequence":"first","affiliation":[{"name":"College of Pharmacy Yeungnam University Gyeongsan Gyeong\u2010buk Republic of 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