{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:03:00Z","timestamp":1788897780646,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Histone deacetylases (HDACs) are intriguing cancer targets due to their high expression in many tumors. Consequently, inhibition or degradation of HDACs can be beneficial for cancer therapy. Targeted protein degradation using molecular glues represents a promising therapeutic approach, enabling the specific degradation of numerous disease\u2010causing proteins. However, the rational design of molecular glues in a target\u2010based manner remains challenging. A recent study has described the identification of a DCAF16\u2010based covalent linker\u2010less chemical handle for molecular glues. This covalent warhead can be attached to protein of interest ligands to induce the targeted degradation of various protein classes. Inspired by this, we designed and synthesized a new class of DCAF16\u2010based covalent molecular glues utilizing different zinc\u2010binding groups for the targeted degradation of HDACs. This approach led to the discovery of an efficient molecular glue (\n                    <jats:bold>10a<\/jats:bold>\n                    ) that reduced HDAC1 levels in multiple myeloma MM.1S cells in a potent and preferential manner.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70045","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:27:11Z","timestamp":1752074831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["DCAF16\u2010Based Covalent Molecular Glues for Targeted Protein Degradation of Histone Deacetylases"],"prefix":"10.1002","volume":"358","author":[{"given":"Tao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Lepper","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"Malenica","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical 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