{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:34:52Z","timestamp":1787596492231,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Twenty\u2010one novel quinazolin\u20104(3\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010one derivatives were synthesized and evaluated for their cytotoxic effects against the PC3 prostate cancer cell line. Structural characterization was performed using FTIR, NMR, and HRMS spectroscopy. Cytotoxicity assays revealed that compound\n                    <jats:bold>1<\/jats:bold>\n                    exhibited the highest potency (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20094.29\u2009\u00b1\u20090.32\u2009\u00b5M) and selectivity (SI\u2009=\u200920.1) against PC3 cells, surpassing the reference drug sorafenib. Compounds\n                    <jats:bold>10<\/jats:bold>\n                    and\n                    <jats:bold>11<\/jats:bold>\n                    also demonstrated significant selectivity (SI\u2009=\u200912.7 and 12.4, respectively), making them promising candidates for further investigation. Molecular docking studies confirmed strong binding affinities to the androgen receptor (AR), with compound\n                    <jats:bold>1<\/jats:bold>\n                    displaying the most favorable interaction (IFD Glide Score\u2009=\u2009\u221215.137\u2009kcal\/mol, MM\u2010GBSA\u2009=\u2009\u201372.11\u2009kcal\/mol). MD simulations further supported the stability of compound\n                    <jats:bold>1<\/jats:bold>\n                    within the receptor binding site, highlighting key hydrogen bonding and \u03c0\u2013\u03c0 stacking interactions. ADME predictions indicated favorable pharmacokinetic properties, with all active compounds complying with drug\u2010likeness criteria and exhibiting high oral absorption. Overall, these findings suggest that quinazolinone derivatives, particularly compound\n                    <jats:bold>1<\/jats:bold>\n                    , hold significant potential as selective anticancer agents targeting prostate cancer.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70048","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T12:10:33Z","timestamp":1752149433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["2\u2010Propyl\u20103\u2010Aminoquinazoline\u20104(3\n                    <i>H<\/i>\n                    )\u2010one Derivatives as Potential Androgen Receptor Inhibitors: Synthesis and Cytotoxicity Against PC3 Cell Line via In Vitro and In Silico Studies"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8333-035X","authenticated-orcid":false,"given":"Halil","family":"\u015eenol","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Bezmialem Vakif University Fatih Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-1655","authenticated-orcid":false,"given":"Furkan","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Bezmialem Vakif University Fatih Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eeyma","family":"Ate\u015fo\u011flu","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Department of Biotechnology Bezmialem Vakif University Fatih Istanbul T\u00fcrkiye"},{"name":"Faculty of Medicine, Department of Medical Biology Bezmialem Vakif University Fatih Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Tokal\u0131","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology, Faculty of Veterinary Medicine Kafkas University Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Merve","family":"\u015eenol","sequence":"additional","affiliation":[{"name":"Program of Medical Laboratory Techniques, Department of Medical Services and Techniques University of Health Sciences \u00dcsk\u00fcdar Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahri","family":"Akba\u015f","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biology Bezmialem Vakif University Fatih Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5532-8802","authenticated-orcid":false,"given":"Feyzi Sinan","family":"Tokal\u0131","sequence":"additional","affiliation":[{"name":"Kars Vocational School, Department of Material and Material Processing Technologies Kafkas University Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139519"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140702"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106145"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105575"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21877"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2024.10.033"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003442"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"Z.Arslan E.Okuro\u011flu H.\u015eenol andZ.T\u00fcrkmen \u201c1\u2010Benzhydryl\u2010piperazine: Isolation Structure Determination and In Silico Studies for a Novel Potential Narcotic Agent Detected in Sports Supplements \u201dJournal of Food Composition and Analysis2024 106682.","DOI":"10.1016\/j.jfca.2024.106682"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3441-7_7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180819666220922103109"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2022.100880"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","unstructured":"H.Gao J. 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