{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T08:11:01Z","timestamp":1763021461803,"version":"3.45.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tuberculosis (TB) remains a major global health challenge, underscoring the urgent need for new therapeutic options. In this study, a series of salicylidenehydrazine derivatives were synthesized and characterized using spectroscopic techniques. Their antimycobacterial activity was assessed against\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    H37Rv. Among the 35 synthesized compounds, nine demonstrated significant inhibitory activity, with MIC values ranging from 0.78 to 50\u2009\u03bcM. These active molecules were further evaluated against clinical isoniazid\u2010resistant (bearing\n                    <jats:italic>inhA<\/jats:italic>\n                    promoter and\/or\n                    <jats:italic>katG<\/jats:italic>\n                    mutations) and multidrug\u2010resistant (MDR)\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    strains. A particularly potent compound derived from 2\u2010bromo\u20104\u2010nitrosalicylaldehyde exhibited an MIC of 0.78\u2009\u03bcM against H37Rv and demonstrated low MIC values of 6.25, 1.56, and 1.56\u2009\u03bcM against the\n                    <jats:italic>inhA<\/jats:italic>\n                    \u2009+\u2009,\n                    <jats:italic>katG<\/jats:italic>\n                    \u2009+\u2009, and MDR strains, respectively. Molecular docking studies were also conducted to investigate the interaction of active compounds with the target enzyme InhA. Overall, the results indicate that salicylidenehydrazine derivatives represent promising lead structures for the development of new anti\u2010TB agents effective against both drug\u2010sensitive and drug\u2010resistant\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    strains.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70065","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T07:07:48Z","timestamp":1753772868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Promising Antimycobacterial Agents: Salicylidenehydrazines"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4152-069X","authenticated-orcid":false,"given":"Oya","family":"Unsal Tan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-9995","authenticated-orcid":false,"given":"S\u0131va Kr\u0131shna","family":"Vagolu","sequence":"additional","affiliation":[{"name":"Unit for Genome Dynamics, Department of Microbiology University of Oslo Oslo Norway"},{"name":"Research, Institute of Internal Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-6921","authenticated-orcid":false,"given":"Tone","family":"T\u00f8njum","sequence":"additional","affiliation":[{"name":"Unit for Genome Dynamics, Department of Microbiology University of Oslo Oslo Norway"},{"name":"Unit for Genome Dynamics, Department of Microbiology Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozan","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-6336","authenticated-orcid":false,"given":"Rahime","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"volume-title":"World Health 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