{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:18:46Z","timestamp":1774653526895,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Aminobenzimidazole\u2010coumaranone conjugates, specifically 3\u2010{[(1<jats:italic>H<\/jats:italic>\u2010benzo[<jats:italic>d<\/jats:italic>]imidazol\u20102\u2010yl)amino](substitutedphenyl)methyl}benzofuran\u20102(3<jats:italic>H<\/jats:italic>)\u2010ones, were synthesized through a one\u2010pot reaction involving 2\u2010coumaranone, aryl aldehydes, and 2\u2010aminobenzimidazole. This reaction, catalyzed by triethylamine in acetonitrile at 80\u00b0C, achieved yields of up to 85%. Preparative liquid chromatography successfully isolated compounds <jats:bold>4b<\/jats:bold> and <jats:bold>4c<\/jats:bold> as two isomers with purities reaching 99.30%. Their absolute configurations, (<jats:italic>S<\/jats:italic>, <jats:italic>R<\/jats:italic>) for compound <jats:bold>4b<\/jats:bold> and (<jats:italic>R<\/jats:italic>, <jats:italic>S<\/jats:italic>) for compound <jats:bold>4c<\/jats:bold>, were determined using electronic circular dichroism and confirmed via TD\u2010DFT calculations. The antimicrobial potential of the synthesized compounds (<jats:bold>4a\u2013j<\/jats:bold>) and their enantiopure isomers (<jats:bold>4b\u2032<\/jats:bold>, <jats:bold>4b\u2033<\/jats:bold>, <jats:bold>4c\u2032<\/jats:bold>, <jats:bold>4c\u2033<\/jats:bold>) was evaluated against the bacterial strains <jats:italic>Bacillus subtilis<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Staphylococcus proteolyticus<\/jats:italic>, and the fungal strains <jats:italic>Candida albicans<\/jats:italic> and <jats:italic>Aspergillus niger<\/jats:italic>. Notably, compounds <jats:bold>4a<\/jats:bold>, <jats:bold>4d<\/jats:bold>, <jats:bold>4i<\/jats:bold>, and <jats:bold>4j<\/jats:bold> exhibited superior antimicrobial activity. Molecular docking studies further reinforced these results, revealing strong receptor binding affinities (\u22127.5 to \u221210.5\u2009kcal\/mol), which surpass those of standard drugs. These findings highlight the promising potential of aminobenzimidazole\u2010coumaranone conjugates as effective antimicrobial agents.<\/jats:p>","DOI":"10.1002\/ardp.70069","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T05:56:38Z","timestamp":1754891798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["One\u2010Pot Synthesis of Novel 3\u2010{(1<i>H<\/i>\u2010Benzo[<i>d<\/i>]Imidazol\u20102\u2010yl)Amino(Phenyl)Methyl}Benzofuran\u20102(3<i>H<\/i>)\u2010Ones as Antimicrobial Agents and Their Molecular Docking Studies"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-6367","authenticated-orcid":false,"given":"Paras J.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Chemistry Sardar Patel University Vallabh Vidyanagar Gujarat India"},{"name":"Shri R. P. Arts Shri K. B. Commerce and Smt. B. C. J. 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