{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:37:37Z","timestamp":1782931057108,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The antiplasmodial properties of a series of fluorinated peptoid\u2010capped histone deacetylase inhibitors (HDACi) were investigated against asexual blood stages of the drug\u2010sensitive 3D7 and drug\u2010resistant Dd2 strains of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    , as well as the exo\u2010erythrocytic liver stages and mature gametocytes. Among the series, compound\n                    <jats:bold>1h<\/jats:bold>\n                    emerged as the most potent derivative, showing strong activity against both\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    strains (\n                    <jats:italic>Pf<\/jats:italic>\n                    3D7 and Dd2 IC\n                    <jats:sub>50<\/jats:sub>\n                    : 0.010\u2009\u03bcM) and\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    liver stages (\n                    <jats:italic>Pb<\/jats:italic>\n                    EEF IC\n                    <jats:sub>50<\/jats:sub>\n                    : 0.74\u2009\u03bcM), while lacking activity against mature gametocytes. Compound\n                    <jats:bold>1b<\/jats:bold>\n                    was identified as a second hit compound with slightly lower activity against asexual blood and liver stages (\n                    <jats:italic>Pf<\/jats:italic>\n                    3D7 IC\n                    <jats:sub>50<\/jats:sub>\n                    : 0.019\u2009\u03bcM;\n                    <jats:italic>Pf<\/jats:italic>\n                    Dd2 IC\n                    <jats:sub>50<\/jats:sub>\n                    : 0.023\u2009\u03bcM;\n                    <jats:italic>Pb<\/jats:italic>\n                    EEF IC\n                    <jats:sub>50<\/jats:sub>\n                    : 2.25\u2009\u03bcM) but showed excellent parasite selectivity (SI\n                    <jats:sup>HepG2\/3D7<\/jats:sup>\n                    : 2389; SI\n                    <jats:sup>HepG2\/Dd2<\/jats:sup>\n                    : 1973) and low single\u2010digit micromolar activity against mature gametocytes (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 1.70\u2009\u03bcM). Compared to our previous hit compound MAHA\u2010022, both\n                    <jats:bold>1b<\/jats:bold>\n                    and\n                    <jats:bold>1h<\/jats:bold>\n                    exhibited improved activity against asexual blood stages and enhanced parasite selectivity, albeit with reduced activity against liver stage parasites. Taken together, compounds\n                    <jats:bold>1b<\/jats:bold>\n                    and\n                    <jats:bold>1h<\/jats:bold>\n                    represent promising multi\u2010stage antiplasmodial HDACi scaffolds for further development and optimization.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70071","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T05:54:51Z","timestamp":1754891691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploration of Fluorinated Peptoid\u2010Based Histone Deacetylase Inhibitors as Dual\u2010Stage Antiplasmodial Agents"],"prefix":"10.1002","volume":"358","author":[{"given":"Nina","family":"Re\u00dfing","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn Bonn 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A.","family":"Winzeler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine University of California San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7970-1429","authenticated-orcid":false,"given":"Jana","family":"Held","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tropenmedizin Eberhard Karls Universit\u00e4t T\u00fcbingen T\u00fcbingen Germany"},{"name":"German Center for Infection Research (DZIF) Partner Site T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9765-5975","authenticated-orcid":false,"given":"Finn K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn Bonn 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