{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T07:27:45Z","timestamp":1763191665977,"version":"3.45.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Four previously unreported tigliane diterpenes (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>6<\/jats:bold>\n                    ), along with two known tiglianes (\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    ), were isolated from the latex of\n                    <jats:italic>Euphorbia palustris<\/jats:italic>\n                    and\n                    <jats:italic>Euphorbia lucida<\/jats:italic>\n                    . The structures of the isolated compounds were elucidated by spectroscopic techniques. Antiviral activity assays for compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2012\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    against HIV\u20101 and HIV\u20102 replication were performed on a CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell line, MT\u20104 cells. The compounds were tested for their ability to inhibit infection by the HIV\u20101 strain NL4.3 and the HIV\u20102 strain ROD. Compound\n                    <jats:bold>6<\/jats:bold>\n                    showed no activity against either strain, while compound\n                    <jats:bold>4<\/jats:bold>\n                    was only slightly active against HIV\u20102 (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200912.778\u2009\u00b5M). Compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    , and\n                    <jats:bold>3<\/jats:bold>\n                    were able to inhibit both HIV\u20101 and HIV\u20102 infections. Among them, compound\n                    <jats:bold>2<\/jats:bold>\n                    was the most potent, with EC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.069\u2009\u00b5M for HIV\u20101 NL4.3 and 0.023\u2009\u00b5M for HIV\u20102 ROD. The PBMC toxicity profile for compound\n                    <jats:bold>2<\/jats:bold>\n                    is also more favorable compared with MT\u20104 cells with CC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200950 \u03bcM.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70080","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:11:06Z","timestamp":1756894266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Anti\u2010HIV Agents Isolated From Two\n                    <i>Euphorbia<\/i>\n                    Species"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-6178","authenticated-orcid":false,"given":"Gordana B.","family":"Krsti\u0107","sequence":"first","affiliation":[{"name":"Department of Organic Cheamistry University of Belgrade\u2014Faculty of Chemistry  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Schols","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation Division of Virology and Chemotherapy, KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Claes","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation Division of Virology and Chemotherapy, KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milka B.","family":"Jadranin","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Belgrade\u2014Institute of Chemistry, Technology and Metallurgy  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris M.","family":"Mandi\u0107","sequence":"additional","affiliation":[{"name":"Department of Organic Cheamistry University of Belgrade\u2014Faculty of Chemistry  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlo","family":"Wittine","sequence":"additional","affiliation":[{"name":"Selvita Ltd.  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vele V.","family":"Te\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Department of Organic Cheamistry University of Belgrade\u2014Faculty of Chemistry  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr078350s"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400541j"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115574"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"652","article-title":"Why do Euphorbiaceae Tick as Medicinal Plants? A Review of Euphorbiaceae Family and Its Medicinal Features","volume":"5","author":"Mwine J. 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