{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T07:24:16Z","timestamp":1763191456391,"version":"3.45.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Microtubules are crucial for various cellular processes, including cell division, where they form highly dynamic spindle fibers for chromosomal alignment and segregation. Interference with microtubule dynamics through microtubule targeting agents (MTAs) blocks progression through mitosis, ultimately resulting in apoptosis. Although MTAs have been effectively used as a frontline treatment for various cancers, multidrug resistance (MDR) often limits their effectiveness. This study focuses on selenadiazoles, a group of organic selenium compounds with anticancer activities. Eighteen novel 1,2,5\u2010selenadiazole derivatives were synthesized, three of which (\n                    <jats:bold>9d<\/jats:bold>\n                    ,\n                    <jats:bold>9f<\/jats:bold>\n                    , and\n                    <jats:bold>9i<\/jats:bold>\n                    ) showed potent antiproliferative activity in HCT116 colorectal cancer cells. Treatment of cells with\n                    <jats:bold>9f<\/jats:bold>\n                    (SSE1706), one of the most potent compounds (GI\n                    <jats:sub>50<\/jats:sub>\n                    value of 1.89\u2009\u00b1\u20090.99\u2009\u00b5M), disrupted mitotic spindle formation, leading to G2\/M arrest.\n                    <jats:bold>9f<\/jats:bold>\n                    inhibited microtubule polymerization in cell\u2010based assays, and long\u2010term treatment with\n                    <jats:bold>9f<\/jats:bold>\n                    stabilized p53 and induced apoptosis. Moreover,\n                    <jats:bold>9f<\/jats:bold>\n                    effectively inhibited the growth of mouse and human colon cancer\u2010derived organoids. Finally,\n                    <jats:bold>9f<\/jats:bold>\n                    exhibited potent antiproliferative activity against MDR\u20101 overexpressing KB\u2010V1 cells, highlighting its potential to overcome MDR. These findings suggest\n                    <jats:bold>9f<\/jats:bold>\n                    as a lead compound for further optimization studies, particularly targeting MDR.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70087","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:04:00Z","timestamp":1756893840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Identification, and Characterization of a Novel 1,2,5\u2010Selenadiazole Derivative as a Microtubule Targeting Agent That Overcomes Multidrug Resistance"],"prefix":"10.1002","volume":"358","author":[{"given":"Farhat","family":"Firdous","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering Lahore University of Management Sciences Lahore Pakistan"},{"name":"Department of Life Sciences, Syed Babar Ali School of Science and Engineering Lahore University of Management Sciences Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Usama Bin","family":"Farrukh","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering Lahore University of Management Sciences Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Furqan","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Syed Babar Ali School of Science and Engineering Lahore University of Management Sciences Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Shaukat","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Syed Babar Ali School of Science and Engineering Lahore University of Management Sciences Lahore 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Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin B.","family":"Myant","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Cancer The University of Edinburgh, Western General Hospital Campus Crewe Road Edinburgh EH4 2XU Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatimah","family":"Alahmari","sequence":"additional","affiliation":[{"name":"Department of Nanomedicine, Institute for Research and Medical Consultations (IRMC) Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul\u2010Hamid","family":"Emwas","sequence":"additional","affiliation":[{"name":"KAUST Core Labs King Abdullah University of Science and Technology Thuwal Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Jaremko","sequence":"additional","affiliation":[{"name":"Division of Biological and Environmental 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