{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:57:51Z","timestamp":1761555471997,"version":"build-2065373602"},"reference-count":84,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The antidiabetic efficacy of\n                    <jats:italic>Elaeocarpus grandis<\/jats:italic>\n                    , belonging to the Family Elaeocarpaceae, was investigated using the streptozotocin\u2010induced hyperglycemia model. The ethyl acetate and petroleum ether fractions demonstrated a notable hypoglycemic impact in a rat model of type 2 diabetes mellitus (T2DM), compared to the negative control group. The chemical assessment of these fractions resulted in the isolation and identification of six known compounds (\n                    <jats:bold>17\u201322<\/jats:bold>\n                    ). LC\u2010HR\u2010ESI\u2010MS metabolomic profiling yielded the provisional identification of sixteen metabolites (\n                    <jats:bold>1\u201316<\/jats:bold>\n                    ) across various chemical classes. In silico investigations, encompassing molecular docking and dynamics simulations, indicated that the compounds heterophylliin A (\n                    <jats:bold>22<\/jats:bold>\n                    ), as well as habbemine A (\n                    <jats:bold>12<\/jats:bold>\n                    ) and elaeocarpinoside (\n                    <jats:bold>15<\/jats:bold>\n                    ), can interact with critical enzymes implicated in glucose metabolism, specifically dipeptidyl peptidase\u2010IV and aldose reductase. Moreover, heterophylliin A (\n                    <jats:bold>22<\/jats:bold>\n                    ) markedly decreased the expression of inflammatory markers (\n                    <jats:italic>IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20106<\/jats:italic>\n                    , and\n                    <jats:italic>TGF\u2010\u03b2<\/jats:italic>\n                    ) in diabetic rats. These findings prompt additional research on\n                    <jats:italic>E. grandis<\/jats:italic>\n                    , specifically its bioactive constituent heterophylliin A, which exhibits intriguing antidiabetic effects and warrants further exploration as a potential treatment agent for T2DM.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70110","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:50:31Z","timestamp":1759499431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Antidiabetic Potential of Heterophylliin A From\n                    <i>Elaeocarpus grandis<\/i>"],"prefix":"10.1002","volume":"358","author":[{"given":"Sherif A.","family":"Maher","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy New Valley University El\u2010kharga City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radwa Taher Mohie","family":"el\u2010dien","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy New Valley University El\u2010kharga City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhamad","family":"Mustafa","sequence":"additional","affiliation":[{"name":"IBMM, Univ Montpellier, CNRS, ENSCM Montpellier France"},{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Deraya University Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amgad I. M.","family":"Khedr","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Port Said University Port Said Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Nahda University Beni\u2010Suef Egypt"},{"name":"Department of Pharmacognosy, College of Pharmacy Almaaqal University Basra Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-6922","authenticated-orcid":false,"given":"Usama Ramadan","family":"Abdelmohsen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Minia University Minia Egypt"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy Deraya University Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa A.","family":"Fouad","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Minia University Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Salah","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Minia University Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"2075","article-title":"Natural Products as Potential Sources of Antidiabetic Drugs","volume":"4","author":"Osadebe P. 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