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The overexpression of c\u2010KIT\u00a0has been implicated with the pathogenesis of several malignancies, such as gastrointestinal stromal tumors, acute myeloid leukemia (AML), mastocytosis, and melanoma. Mutation of c\u2010KIT has been observed in acral, mucosal, and chronically sun\u2010damaged melanoma subtypes marking it\u00a0as a key therapeutic target for melanoma. Moreover, the increasing incidence and mortality rate associated with melanoma further marks the importance of developing new therapeutic modalities. Herein, the progress in the design, structure\u2013activity relationship, mechanisms, and development of c\u2010KIT small molecule inhibitors for melanoma is discussed with the aim of guiding future c\u2010KIT\u2010based melanoma therapeutics.<\/jats:p>","DOI":"10.1002\/ardp.70113","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:51:41Z","timestamp":1759499501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["c\u2010KIT Small Molecule Inhibitors as a Therapeutic Strategy for Melanoma: Clinical Insights, SAR, and Future Directions"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0594-1685","authenticated-orcid":false,"given":"Shubham C.","family":"Rivonker","sequence":"first","affiliation":[{"name":"BK21 FOUR Team and Integrated Research, Institute for Drug Development, College of Pharmacy Dongguk University, Seoul Goyang Republic of 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