{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:59:44Z","timestamp":1761555584836,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sixteen novel selenoderivatives of flutamide, which is used for treating androgen receptor (AR)\u2010dependent prostate cancer, were developed. All the Se derivatives displayed promising activity against the NCI\u201060 human cancer cell line panel, which also includes two AR\u2010independent prostate cancer cell lines, DU\u2010145 and PC\u20103. Conversely to flutamide, compounds\n                    <jats:bold>a2<\/jats:bold>\n                    ,\n                    <jats:bold>a5<\/jats:bold>\n                    , and\n                    <jats:bold>b4<\/jats:bold>\n                    exhibited a potent antiproliferative effect toward AR\u2010dependent LNCaP cells. Several cell death inhibitors were used to determine the underlying regulated cell death processes of\n                    <jats:bold>a5<\/jats:bold>\n                    . Regarding its mechanism of action in these cells, this compound promoted apoptosis by activating both intrinsic and extrinsic apoptotic pathways, without generating reactive oxygen species (ROS). Besides, it induced the G0\/G1 cell cycle arrest. Altogether, it could be concluded that this Se\u2010flutamide analog could be a feasible and promising candidate for further development for the treatment of both AR\u2010dependent and \u2010independent prostate cancers.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70119","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T06:28:47Z","timestamp":1760682527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Innovative Se\u2010Flutamide Derivatives: Enhanced Activity Toward Androgen Receptor (AR)\u2010Dependent and \u2010Independent Prostate Cancer Cells"],"prefix":"10.1002","volume":"358","author":[{"given":"Cristina","family":"Mor\u00e1n\u2010Serradilla","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Navarra Irunlarrea Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3431-7826","authenticated-orcid":false,"given":"Carmen","family":"Sanmart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Navarra Irunlarrea Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Molecular and Precision Medicine Penn State Cancer Institute, Penn State College of Medicine Hershey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Enc\u00edo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Public University of Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-0445","authenticated-orcid":false,"given":"Daniel","family":"Plano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Navarra Irunlarrea Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Molecular and Precision Medicine Penn State Cancer Institute, Penn State College of Medicine Hershey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.119085"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00373-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2010.10.051"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2021.107484"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.01.054"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02426"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25033"},{"key":"e_1_2_8_10_1","first-page":"1171","article-title":"Selenium Effects on Prostate Cell Growth","volume":"9","author":"Menter D. 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