{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:25:22Z","timestamp":1764563122952,"version":"3.46.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Retinoic acid receptor\u2010related orphan receptor gamma\u2010t (ROR\u03b3t) is one of the nuclear receptor transcription factors that plays a key role in the differentiation of pro\u2010inflammatory IL\u201017\n                    <jats:sup>+<\/jats:sup>\n                    T helper cells. Recently, ROR\u03b3t has attracted increasing attention as a potential drug target for the treatment of several human inflammatory diseases, including psoriasis and Crohn's disease. In this study, we revealed that ergosterol (ERG) was a novel ROR\u03b3t inverse agonist, which decreased ROR\u03b3t transcriptional activity, to regulate collagen fiber deposition and to inhibit pro\u2010inflammatory cytokines, including TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, IL\u201017, IL\u201022, and IL\u201023 in the skin lesions of IMQ\u2010induced mice with psoriasis. Furthermore, ERG could repair the epidermal barrier function by upregulating tight junction proteins, such as claudin, occludin, and ZO\u20101, thereby alleviating psoriasis symptoms. These findings suggested that ERG might be used as a promising novel ROR\u03b3t inverse agonist in the management of psoriasis.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70121","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T04:16:09Z","timestamp":1762402569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ergosterol, a Novel ROR\u03b3t Inverse Agonist, Enhances Skin Barrier Function and Reduces Skin Inflammation in IMQ\u2010Induced Mice With Psoriasis"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8469-1473","authenticated-orcid":false,"given":"Ling","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangdong Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4131-5522","authenticated-orcid":false,"given":"Jiangming","family":"Zhong","sequence":"additional","affiliation":[{"name":"HBN Research Institute and Biological Laboratory, Shenzhen Hujia Technology Co. 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