{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:57:44Z","timestamp":1761555464992,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Piperidine antimycotics like fenpropidin are well established in agrochemistry. On the other hand, numerous isoquinoline derivatives show remarkable antimycotic effects. Here we present a series of 13 hybrid molecules of both lead structures, which were prepared using reductive amination as key reaction step. Pre\u2010screening against\n                    <jats:italic>Yarrowia lipolytica<\/jats:italic>\n                    resulted in a batch of promising candidates whose antifungal efficacy was further evaluated against clinically relevant species. In these assays, complete growth inhibition was seen for five or six compounds against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    or\n                    <jats:italic>C. krusei<\/jats:italic>\n                    , respectively, and in two against\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    , whereas no antifungal activity was observed against mold isolates, with the exception of\n                    <jats:bold>6i<\/jats:bold>\n                    , which led to complete growth inhibition of aspergilli, and two compounds (\n                    <jats:bold>6k<\/jats:bold>\n                    and\n                    <jats:bold>6\u2009l<\/jats:bold>\n                    ) that were able to inhibit\n                    <jats:italic>Rhizopus arrhizus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/ardp.70128","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T06:34:44Z","timestamp":1760682884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Biological Evaluation of Novel 2\u2010(Piperidin\u20104\u2010yl)\u20101,2,3,4\u2010tetrahydroisoquinoline and 2\u2010(Piperidin\u20104\u2010yl)decahydroisoquinoline Antimycotics"],"prefix":"10.1002","volume":"358","author":[{"given":"Marie\u2010Christin","family":"Hain","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Center of Drug Research Ludwig\u2010Maximilians University Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Klimt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center of Drug Research Ludwig\u2010Maximilians University Munich Munich 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