{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:25:25Z","timestamp":1764563125586,"version":"3.46.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the current study, a series of 22 prenylated arylidene appended thiazolidinedione derivatives were designed, synthesized, and evaluated for pancreatic lipase (PL) inhibitory activity. The study led to the identification of compounds exhibiting potent to moderate inhibitory activities with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging between 6.18\u2009\u00b1\u20090.46 and 52.75\u2009\u00b1\u20092.34\u2009\u00b5M. Among them, compound\n                    <jats:bold>22b<\/jats:bold>\n                    demonstrated remarkable PL inhibitory activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 6.18\u2009\u00b1\u20090.46\u2009\u00b5M. Enzyme kinetics studies revealed a reversible competitive mode of inhibition for\n                    <jats:bold>22b<\/jats:bold>\n                    with a\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>i<\/jats:italic>\n                    <\/jats:sub>\n                    value of 4.1\u2009\u03bcM. The results of in vitro findings further supported the outcome of in silico studies, which correlate the strong binding affinity of compound\n                    <jats:bold>22b<\/jats:bold>\n                    for PL. Molecular docking studies confirmed satisfactory binding mode of compounds within the active site of PL by exhibiting various interactions such as H\u2010bonding, \u03c0\u2013\u03c0 stacking, and hydrophobic interactions. A 100\u2009ns molecular dynamics simulation study of protein\u2013ligand complex with compound\n                    <jats:bold>22b<\/jats:bold>\n                    revealed good binding and stability. The MM\u2010GBSA analysis revealed strong binding affinity toward the active site of PL as compared with the reference ligand. Further, all derivatives were predicted to exhibit good pharmacokinetic properties, devoid of toxicity (toxicity class 4) and drug likeness.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70135","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:25:06Z","timestamp":1762838706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Pharmacological Evaluation of Prenylated Arylidene\u2010Substituted Thiazolidinedione\u2010Based Pancreatic Lipase Inhibitors as Anti\u2010obesity Agents"],"prefix":"10.1002","volume":"358","author":[{"given":"Rakesh","family":"Khator","sequence":"first","affiliation":[{"name":"Drug Design and Molecular Synthesis Laboratory, Department of Pharmaceutical Sciences and Natural Products Central University of Punjab Bathinda Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utkarsh 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