{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:26:21Z","timestamp":1764563181717,"version":"3.46.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ulcerative colitis (UC) is a persistent inflammatory bowel disorder characterized by systemic inflammation and oxidative stress. This study compared the therapeutic potential of lamotrigine and donepezil in an acetic acid (AA)\u2010induced UC rat model. Fifty\u2010six male Wistar rats were divided into seven groups: control, AA (4% v\/v), donepezil (5\u2009mg\/kg), lamotrigine (10\u2009mg\/kg), prednisolone + AA, donepezil + AA, and lamotrigine + AA. Treatments were trans\u2010rectally administered for 12 days before and 2 days after UC induction. Macroscopic and histological damage, oxidative stress markers (myeloperoxidase, malondialdehyde, and nitric oxide), antioxidant levels (glutathione), cytokines, and apoptotic markers were assessed. Donepezil and lamotrigine reduced AA\u2010induced damage, decreased oxidative stress, and restored the glutathione level. Both drugs lowered proinflammatory cytokines (e.g., interleukin\u20101\u03b2 and tumor necrosis factor\u2010\u03b1) and increased interleukin\u201010. Mechanistically, they activated peroxisome proliferator\u2010activated receptor\u2010gamma (PPAR\u03b3), inhibited nuclear factor kappa B (NF\u03baB), and modulated apoptosis (BAX\/Bcl\u20102 ratio, caspase\u20101). Donepezil and lamotrigine show promise in UC therapy by targeting oxidative stress, inflammation, and apoptosis, supporting their potential repurposing for inflammatory bowel disease treatment. Further research is needed for clinical validation.<\/jats:p>","DOI":"10.1002\/ardp.70141","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:14:31Z","timestamp":1762838071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Donepezil and Lamotrigine in Modulating NF\u03baB, PPAR\u03b3, and NLRP3 Inflammasome Pathways in Experimental Colitis"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9858-829X","authenticated-orcid":false,"given":"Nourhan S.","family":"Abdeltwab Desoky","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing Misr University for Science and Technology Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha A. 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