{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:13:30Z","timestamp":1781813610123,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the pursuit of novel agents for treating leishmaniasis and cancer, we have synthesized a small library of phenylcarboxamide\u2010selenium analogs and evaluated their in vitro antileishmanial, anticancer, and carbonic anhydrase inhibitory activities. The two trifluoromethoxy\u2010substituted aniline derivatives (\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    ) exhibited IC\n                    <jats:sub>50<\/jats:sub>\n                    values in the low micromolar range in both\n                    <jats:italic>Leishmania major<\/jats:italic>\n                    and\n                    <jats:italic>Leishmania infantum<\/jats:italic>\n                    promastigotes and presented better selectivity indexes (SIs) than the reference drugs (miltefosine and paromomycin). Furthermore, all of the reported compounds displayed an outstanding antitumoral activity against a panel of 60 cancer cell lines of the National Cancer Institute's (NCI) Developmental Therapeutic Program (DTP). The cytotoxicity of compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    in nonmalignant HaCaT cells was also evaluated. Furthermore, as several selenocompounds have previously been proven to inhibit tumor\u2010associated human carbonic anhydrase (hCA) isoforms, all the compounds were assessed against hCA I, II, IX, and XII. Derivative\n                    <jats:bold>6<\/jats:bold>\n                    stood out as it inhibited tumor\u2010associated isoform XII and the cytosolic hCA II isoform in the low micromolar range.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70145","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T07:59:46Z","timestamp":1764835186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Se\u2010Compounds With Antileishmanial, Antitumor, and Carbonic Anhydrase Inhibitory Properties"],"prefix":"10.1002","volume":"358","author":[{"given":"Cristina","family":"Mor\u00e1n\u2010Serradilla","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Plano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angelli","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section University of Firenze Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Molecular and Precision Medicine Penn State College of Medicine Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Sanmartin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section University of Firenze Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2191165"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2023.117467"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.05.073"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202401587"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.08.096"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1548608"},{"key":"e_1_2_8_8_1","first-page":"3","article-title":"Advances in Anti\u2010Cancer Drug Development Targeting Carbonic Anhydrase IX and XII","volume":"5","author":"Mboge M. 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