{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:17:33Z","timestamp":1772997453664,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The development of theranostic probes with tumor\u2010specific targeting and high therapeutic efficacy remains a pivotal challenge in precision oncology. Herein, we have successfully developed a new cyclooxygenase\u20102 (COX\u20102)\u2010targeted probe compound\n                    <jats:bold>2<\/jats:bold>\n                    derived from Rofecoxib. Compound\n                    <jats:bold>2<\/jats:bold>\n                    facilitated tumor visualization by a sixfold fluorescence enhancement upon COX\u20102 binding, while it exhibited minimal background fluorescence under physiological conditions. Moreover, compound\n                    <jats:bold>2<\/jats:bold>\n                    monotherapy achieved 53% tumor regression (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). When combined with a programmed cell death protein 1 (PD\u20101) inhibitor (RMP1\u201014), concurrent blockade of the COX\u20102\/prostaglandin E2 (PGE2) and PD\u20101\/programmed death\u2010ligand 1 (PD\u2010L1) axes achieved 95% tumor regression (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Compound\n                    <jats:bold>2<\/jats:bold>\n                    involves activating fluorescence by targeting tumor markers COX\u20102 as well as enhancing therapeutic efficacy. We believe this approach could provide insights for advancing cancer diagnosis and treatment technologies.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70155","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T06:16:21Z","timestamp":1765520181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rofecoxib\u2010Derived Theranostic Probe and Its Combination With PD\u20101 Inhibitor for High\u2010Efficiency Cancer Therapy"],"prefix":"10.1002","volume":"358","author":[{"given":"Xinli","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital Fuzhou Fujian People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology Fuzhou Fujian People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejing","family":"Su","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology Fuzhou Fujian People's Republic of China"},{"name":"College of Life Sciences Fujian Agriculture and Forestry University Fuzhou Fujian People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexin","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology Fuzhou Fujian People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology Fuzhou Fujian People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-6587","authenticated-orcid":false,"given":"Lijun","family":"Xie","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Screening for Novel Microbial Products Fujian Institute of Microbiology Fuzhou Fujian People's Republic of China"},{"name":"College of Life Sciences Fujian Agriculture and Forestry University Fuzhou Fujian People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fujian Medical University Union Hospital Fuzhou Fujian People's Republic of 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