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These 11 molecules have been characterized by spectroscopic techniques such as FT\u2010IR, NMR (\n                    <jats:sup>1<\/jats:sup>\n                    H and\n                    <jats:sup>13<\/jats:sup>\n                    C), and single\u2010crystal x\u2010ray structural analysis. The Hirshfeld surface and 2D fingerprint plot elucidated the intermolecular interactions and their contribution to crystal packing. Furthermore, the computational calculations, such as FMOs and MEP, revealed the global reactivity descriptors and sites for noncovalent interactions, such as hydrogen bonding, respectively, in these pharmacophores. Among these derivatives, the\n                    <jats:bold>6h<\/jats:bold>\n                    molecule, which bears \u2013CF\n                    <jats:sub>3<\/jats:sub>\n                    on the phenyl ring, has piperidine substitution on the ester group and contains a thiourea moiety, demonstrated the best larvicidal activity against\n                    <jats:italic>Anopheles arabiensis<\/jats:italic>\n                    , achieving a 94% mortality rate compared to the standard sample Temephos (98%).\n                  <\/jats:p>","DOI":"10.1002\/ardp.70162","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T08:10:28Z","timestamp":1764835828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Solvent and Catalyst\u2010Free One\u2010Pot Synthesis of Tetrahydropyrimidine Analogs for Their Larvicidal Activity and Structural Insights"],"prefix":"10.1002","volume":"358","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-9601","authenticated-orcid":false,"given":"Keshab M.","family":"Bairagi","sequence":"first","affiliation":[{"name":"Department of Chemistry Visvesvaraya National Institute of Technology Nagpur Maharashtra India"},{"name":"Postgraduate Teaching Department of Chemistry Gondwana University Gadchiroli Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-7270","authenticated-orcid":false,"given":"Sandeep","family":"Chandrashekharappa","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER\u2010R), Raebareli Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-6592","authenticated-orcid":false,"given":"Jyoti Swarup","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Chemistry Visvesvaraya National Institute of Technology Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9695-0833","authenticated-orcid":false,"given":"Rahul D.","family":"Nagdeve","sequence":"additional","affiliation":[{"name":"Department of Chemistry Visvesvaraya National Institute of Technology Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-8378","authenticated-orcid":false,"given":"Rohit","family":"Bhowal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Science Education and Research Bhopal Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6772-167X","authenticated-orcid":false,"given":"Manasmita","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Science Education and Research Bhopal Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-6007","authenticated-orcid":false,"given":"Deepak","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Science Education and Research Bhopal Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-2639","authenticated-orcid":false,"given":"Raquel M.","family":"Gleiser","sequence":"additional","affiliation":[{"name":"CREAN\u2010IMBIV (CONICET\u2010UGC), AV Valparaiso s.n., and FCEFyN, AV. 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