{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:33:40Z","timestamp":1787639620086,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer prevails a substantial health threat, with breast and colon cancers being the second and third most recurrent worldwide. In recent decades, quinoline\/pyrido[2,3\u2010d]pyrimidin\u20104(3H)\u2010one derivatives have procured attention as propitious anticancer agents. This study acquaint a series of such compounds synthesized and characterized using spectroscopic (1H NMR, 13C NMR, IR, MS) and computational (DFT) methods. Their tubulin polymerization inhibitory and antiproliferative activities were assessed against cancer cell lines MCF\u20107, MDA\u2010MB\u2010231, and HCT\u2010116, accompanying cytotoxicity screening against normal HEK\u2010293 cells, divulging selective anticancer potential. SAR study accentuated the role of methoxy\u2010substituted phenyl and cycloheptane rings in escalating activity. Peculiarly, compound\n                    <jats:bold>4g<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20093.02\u2009\u00b1\u20090.63\u2009\u03bcM against cell line MCF\u20107) exhibited profound tubulin inhibition and was additionally substantiated via molecular docking and dynamics simulations, ratifying its drug\u2010like behavior.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70172","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T10:45:32Z","timestamp":1766227532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quinoline\/Pyrido\u2010Pyrimidine Derivatives as Tubulin Polymerization Inhibitors: Design, Synthesis, Computational, and Anticancer Evaluation"],"prefix":"10.1002","volume":"358","author":[{"given":"Divyakshi","family":"Arya","sequence":"first","affiliation":[{"name":"Department of Chemistry D.D.U. Gorakhpur University Gorakhpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulshan Aara","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Chemistry D.D.U. Gorakhpur University Gorakhpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7748-4418","authenticated-orcid":false,"given":"Shweta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry D.D.U. Gorakhpur University Gorakhpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Chemistry D.D.U. Gorakhpur University Gorakhpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8700-9697","authenticated-orcid":false,"given":"Bharat Prasad","family":"Sharma","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Beijing University of Chemical Technology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4839-0875","authenticated-orcid":false,"given":"Rajesh","family":"Maharjan","sequence":"additional","affiliation":[{"name":"Central Department of Physics Tribhuvan University Kirtipur Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motee Lal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Central Department of Chemistry Tribhuvan University Kirtipur Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munna P.","family":"Gupt","sequence":"additional","affiliation":[{"name":"Department of Chemistry D.A.V. 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