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In this study, we investigated the metabolic responses of\n                    <jats:italic>P. inhibens<\/jats:italic>\n                    cultured with sinapic acid, an algal\u2010derived lignin catabolite known to modulate algal\u2013bacterial interactions. Detailed LC\u2013MS\/UV\u2010guided analysis of the sinapic acid\u2010treated culture identified 10 metabolites, including two new compounds, roseochelins C (\n                    <jats:bold>1<\/jats:bold>\n                    ) and D (\n                    <jats:bold>2<\/jats:bold>\n                    ). All isolated compounds were tested for anti\u2010allergic effects in Th2 cell\u2013mediated immune responses, and sinatryptin A (\n                    <jats:bold>4<\/jats:bold>\n                    ) showed the strongest activity by reducing Th2 cytokine production and blocking Th2 differentiation through inhibition of the IL\u20104\/STAT6\u2013GATA3\/IRF4 pathway. These findings expand the chemical diversity of algal\u2013bacterial interactions, and anti\u2010allergic assays of the isolated metabolites highlight the potential of\n                    <jats:italic>Roseobacter<\/jats:italic>\n                    \u2010derived compounds as novel bioactive resources.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70192","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:24:18Z","timestamp":1769523858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Algal\u2013Bacterial Interaction\u2010Driven Secondary Metabolites From\n                    <i>Phaeobacter inhibens<\/i>\n                    and Their Anti\u2010Allergic Effects on Th2 Cell Immune Response"],"prefix":"10.1002","volume":"359","author":[{"given":"Jisu","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development Pusan National University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Natural Product Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Cheongju si, Chungcheong\u2010buk\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development Pusan National University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon\u2010Jeong","family":"Hwang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Research Institute for Drug Development Pusan National University Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun 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