{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:41Z","timestamp":1786977101740,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acetylcholinesterase (AChE) is one of the most important therapeutic targets in the treatment of neurological disorders such as Alzheimer's disease. In recent years, studies on the use of carbonic anhydrase (CA) inhibitors in the treatment of Alzheimer's disease have attracted considerable attention. In this study, novel benzene\/5\u2010HMF\u2010chalcone hybrids and their benzoate esters were synthesized. Furthermore, the AChE, carbonic anhydrases I and II (CA I and II) inhibition potentials of the compounds were evaluated through in vitro enzyme inhibition assays and molecular docking studies to identify new potential drug candidate molecules. According to the inhibition results, the\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    values of the synthesized compounds were found to be in the range of 1.51\u20132.91\u2009nM against AChE, 26.15\u201368.66\u2009nM against CA I, and 27.91\u2013107.04\u2009nM against CA II. Molecular docking studies revealed that the compounds bind to both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE, with Glide scores ranging from \u20135.76 to \u20138.50 kcal\/mol. In contrast, the molecules interacted with the active site of CA I\/II by coordinating with the catalytic Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ion. All compounds complied with Lipinski's Rule of Five, indicating favorable drug\u2010like properties. These results suggest that 5\u2010HMF\u2010chalcone hybrids and their benzoate derivatives could serve as promising scaffolds for the development of new anti\u2010Alzheimer's agents. These findings suggest that 5\u2010HMF\u2010chalcone hybrids and their benzoate derivatives may be useful in establishing the structural basis of new anti\u2010Alzheimer's agents.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70198","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:15:24Z","timestamp":1770362124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acetylcholinesterase and Carbonic Anhydrase Inhibition Profiles of New 5\u2010HMF Chalcones and Their Ester Derivatives"],"prefix":"10.1002","volume":"359","author":[{"given":"Ay\u015fe","family":"\u0130lhan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-9538","authenticated-orcid":false,"given":"Ferhat","family":"G\u00fcne\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Atat\u00fcrk University  Erzurum T\u00fcrkiye"},{"name":"Department of Pharmaceutical Chemistry, Institute of Health Sciences Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Ert\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131\u015f","family":"An\u0131l","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Sciences Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Sciences Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-5925","authenticated-orcid":false,"given":"Mehmet","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Atat\u00fcrk University  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01911-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557520666200103100521"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.10.096"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13063"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2021.103645"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100384"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00120-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.137554"},{"key":"e_1_2_8_10_1","first-page":"329","article-title":"A Review: New Synthesis of Chalcone Derivatives and Their Applications","volume":"8","author":"Hamad A. 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