{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:01:55Z","timestamp":1772985715128,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Malaria remains a major global health burden, compounded by increasing resistance to current therapies.\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    carbonic anhydrase (\n                    <jats:italic>Pfa<\/jats:italic>\n                    CA), a\n                    <jats:italic>\u03b7<\/jats:italic>\n                    \u2010class metalloenzyme essential for the parasite metabolism and survival, has recently emerged as a promising antimalarial target. In this study, benzoxaborole\n                    <jats:bold>4<\/jats:bold>\n                    and its 6\u2010substituted triazolyl derivatives (\n                    <jats:bold>5\u201318<\/jats:bold>\n                    ) were evaluated for\n                    <jats:italic>Pfa<\/jats:italic>\n                    CA inhibition and in vitro antiplasmodial activity against the\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    3D7 strain. Compounds\n                    <jats:bold>13<\/jats:bold>\n                    and\n                    <jats:bold>14<\/jats:bold>\n                    emerged as the most potent inhibitors (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>I<\/jats:sub>\n                    \u2009=\u20090.45 and 0.43\u2009\u00b5M, respectively) of the enzyme, coupled with notable antiplasmodial activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200934 and 47\u2009\u00b5M). Among the tested compounds, the ethyl ester\n                    <jats:bold>7<\/jats:bold>\n                    demonstrated the strongest antiplasmodial activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20092.5\u2009\u00b5M). Molecular docking studies further supported the favorable binding of active derivatives within the\n                    <jats:italic>Pfa<\/jats:italic>\n                    CA active site. These findings highlight the potential of benzoxaborole\u2010based scaffolds as a new chemotype for antimalarial drug development.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70201","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T04:49:30Z","timestamp":1770612570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Benzoxaboroles Are Inhibitors of the\n                    <i>\u03b7<\/i>\n                    \u2010Class Carbonic Anhydrase From\n                    <i>Plasmodium falciparum<\/i>"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5520-740X","authenticated-orcid":false,"given":"Alessandro","family":"Bonardi","sequence":"first","affiliation":[{"name":"NEUROFARBA Department, Pharmaceutical and Nutraceutical Section University of Florence Sesto Fiorentino Firenze Italy"},{"name":"NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics &amp; QSAR University of Florence Sesto Fiorentino Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-2413","authenticated-orcid":false,"given":"Sharon","family":"Wein","sequence":"additional","affiliation":[{"name":"LPHI, Univ Montpellier, CNRS, INSERM, Campus Triolet Place Eug\u00e8ne Bataillon Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1384-7556","authenticated-orcid":false,"given":"Muhamad","family":"Mustafa","sequence":"additional","affiliation":[{"name":"IBMM, Univ Montpellier, CNRS ENSCM Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-8006","authenticated-orcid":false,"given":"Rachel","family":"Cerdan","sequence":"additional","affiliation":[{"name":"LPHI, Univ Montpellier, CNRS, INSERM, Campus Triolet Place Eug\u00e8ne Bataillon Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3406-833X","authenticated-orcid":false,"given":"Viviana","family":"de Luca","sequence":"additional","affiliation":[{"name":"Department of Biology, Agriculture and Food Sciences, National Research Council (CNR) Institute of Biosciences and Bioresources Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-2411","authenticated-orcid":false,"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[{"name":"Department of Biology, Agriculture and Food Sciences, National Research Council (CNR) Institute of Biosciences and Bioresources Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-2509","authenticated-orcid":false,"given":"Paola","family":"Gratteri","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics &amp; QSAR University of Florence Sesto Fiorentino Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Pharmaceutical and Nutraceutical Section University of Florence Sesto Fiorentino Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-702X","authenticated-orcid":false,"given":"Alessio","family":"Nocentini","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Pharmaceutical and Nutraceutical Section University of Florence Sesto Fiorentino Firenze Italy"},{"name":"NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics &amp; QSAR University of Florence Sesto Fiorentino Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3197-3414","authenticated-orcid":false,"given":"Jean\u2010Yves","family":"Winum","sequence":"additional","affiliation":[{"name":"IBMM, Univ Montpellier, CNRS ENSCM Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"\u201cWorld Malaria Report 2024 \u201d WHO accessed September 2025 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