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Molecular targeted therapy is characterized by its high precision and low toxicity, which confers a significant advantage in the management of NSCLC. Extensive research has explored the co\u2010targeting of AXL and c\u2010Met in both preclinical and clinical contexts, primarily emphasizing small\u2010molecule inhibitors. This review systematically examines the structure, function, regulatory mechanisms, and signaling pathways of AXL and c\u2010Met. It then highlights recent advancements in small molecule co\u2010targeted inhibitors of AXL and c\u2010Met, detailing their mechanisms of action in NSCLC treatment, and summarizes the results of relevant clinical trials. AXL and c\u2010Met significantly influence NSCLC cell proliferation, migration and invasion, epithelial\u2013mesenchymal transition (EMT), and drug resistance, all of which adversely affect patient prognosis. Co\u2010targeting of AXL and c\u2010Met is considered a promising therapeutic strategy for NSCLC.<\/jats:p>","DOI":"10.1002\/ardp.70211","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T07:31:46Z","timestamp":1773991906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AXL and c\u2010Met Dual\u2010Targeting in Non\u2010Small Cell Lung Cancer: A Review of Small\u2010Molecule Inhibitors and Their Structure\u2013Activity Relationships"],"prefix":"10.1002","volume":"359","author":[{"given":"Haifeng","family":"Dong","sequence":"first","affiliation":[{"name":"School of Pharmacy Jiangxi Science and Technology Normal University Nanchang Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengting","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jiangxi Science and Technology Normal University Nanchang Jiangxi 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