{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:29:43Z","timestamp":1785547783104,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cervical cancer remains a serious threat to women's health due to chemotherapy resistance, poor prognosis, and survival rates. Novel anti\u2010cervical cancer agents are urgently needed. Sinomenine derivatives, which were prepared from sinomenine (a natural morphinane alkaloid), have been previously reported by us to be cytotoxic toward various cancer cell lines. Also, an increase in ROS production, which is associated with ferroptosis, was observed in cancer cells. In this study, we synthesized 18 sinomenine derivatives and evaluated their antitumor activity in vitro against four human tumor cell lines (HeLa, HepG2, A549, and HT\u201029). Five derivatives (\n                    <jats:bold>12<\/jats:bold>\n                    \u2013\n                    <jats:bold>16<\/jats:bold>\n                    ) containing quinoline fragments showed broad\u2010spectrum antitumor activity. Significantly,\n                    <jats:bold>16<\/jats:bold>\n                    showed specific activity against HeLa and HT\u201029 cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.60 and 7.60\u2009\u03bcM, respectively. Its optimal lipophilicity (\u22121 &lt; log\u2009\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u20092) likely contributes to this efficacy. Further study in vitro showed that Derivative\n                    <jats:bold>16<\/jats:bold>\n                    could increase the accumulation of ferrous iron, which caused an increase in ROS levels and MDA contents, and a decrease in GPX4 activity. Western blot results showed that\n                    <jats:bold>16<\/jats:bold>\n                    decreased the FHTI\u2010to\u2010GAPDH, SLC7A11\u2010to\u2010GAPDH, and GPX4\u2010to\u2010GAPDH ratios. Molecular docking simulation results suggested that\n                    <jats:bold>16<\/jats:bold>\n                    can interact with ferroptosis\u2010related proteins\n                    <jats:italic>via<\/jats:italic>\n                    the van der Waals force, and cation\u2013\u03c0, anion\u2013\u03c0, and hydrogen bonding interactions. In brief, Compound\n                    <jats:bold>16<\/jats:bold>\n                    may be a potentially useful drug for the treatment of cervical cancer, as it induces ferroptosis in HeLa cells by inhibiting FTH1 expression and the SLC7A11\/GSH\/GPX4 pathway.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70218","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:15:49Z","timestamp":1772964949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["New Sinomenine Derivative as a Potential Drug for Cervical Cancer\n                    <i>via<\/i>\n                    Inducing Ferroptosis"],"prefix":"10.1002","volume":"359","author":[{"given":"Yifan","family":"Shang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keran","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-1500","authenticated-orcid":false,"given":"Huixian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Equipment Yangchun Hospital of Traditional Chinese Medicine  Yangchun Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guangdong Women and Children Hospital  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqin","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"10","article-title":"Global Burden of Cervical Cancer: A Literature Review","volume":"4","author":"Cecilia N. 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