{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:33:32Z","timestamp":1774622012803,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study reports the synthesis of some novel chalcone (\n                    <jats:bold>C1\u2013C3<\/jats:bold>\n                    ) and 3,5\u2010disubstituted pyrazoline derivatives (\n                    <jats:bold>P1<\/jats:bold>\n                    \u2013\n                    <jats:bold>P3<\/jats:bold>\n                    ), structurally based on aminophenyl and trifluoromethylphenyl groups. Their potential as antidiabetic agents was evaluated through in vitro inhibition of \u03b1\u2010amylase and \u03b1\u2010glucosidase enzymes and supported by molecular docking studies. Among all the compounds,\n                    <jats:bold>P2<\/jats:bold>\n                    showed potent dual inhibition, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 9.35 and 2.10\u2009\u00b5M against \u03b1\u2010amylase and \u03b1\u2010glucosidase, respectively, comparable to or better than the standard inhibitor acarbose. Kinetic studies revealed that\n                    <jats:bold>P2<\/jats:bold>\n                    acts via a non\u2010competitive mechanism for both enzymes. Docking analysis was performed for all of the molecules. These findings suggest that especially\n                    <jats:bold>P2<\/jats:bold>\n                    has significant potential as a lead compound for further antidiabetic drug development.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70222","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:03:59Z","timestamp":1772989439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Some Novel Chalcone and 3,5\u2010Disubstituted Pyrazoline Derivatives: Evaluation of Their \u03b1\u2010Amylase and \u03b1\u2010Glucosidase Inhibitory Activities In Vitro and In Silico"],"prefix":"10.1002","volume":"359","author":[{"given":"Fatma","family":"Erbay","sequence":"first","affiliation":[{"name":"Graduate School of Natural and Applied Science Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4195-4647","authenticated-orcid":false,"given":"Melike Yildirim","family":"Akatin","sequence":"additional","affiliation":[{"name":"Macka Vocational School Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Demir","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuran","family":"Kahriman","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Karadeniz Technical University  Trabzon 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