{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:33:30Z","timestamp":1774622010152,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["1402\u20101\u2010104\u201066003"],"award-info":[{"award-number":["1402\u20101\u2010104\u201066003"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neglected tropical diseases remain a major global health challenge, highlighting the need for new antiparasitic agents. In this study, a series of substituted 1\u2010[5\u2010(5\u2010nitrofuran\u20102\u2010yl)\u20101,3,4\u2010thiadiazol\u20102\u2010yl]piperidine\u20104\u2010carboxamides was designed, synthesized, and evaluated for in vitro antileishmanial and antitrypanosomal activity. Compound\n                    <jats:bold>18<\/jats:bold>\n                    emerged as the most promising derivative, showing submicromolar activity against all tested parasites with acceptable selectivity toward THP\u20101 cells. Mechanistic studies in\n                    <jats:italic>T. b. brucei<\/jats:italic>\n                    bloodstream cells revealed a reversible cytostatic effect rather than apoptosis, and assessment of cellular and mitochondrial ROS levels indicated that oxidative stress was not a primary contributor to activity. In silico ADME analysis supported the drug\u2010likeness of the synthesized compounds. Taken together, these findings identify\n                    <jats:bold>18<\/jats:bold>\n                    as a valuable lead for further antiparasitic drug development.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70227","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:01:15Z","timestamp":1774242075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Novel Nitrofuryl\u20101,3,4\u2010Thiadiazole\u2010Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity"],"prefix":"10.1002","volume":"359","author":[{"given":"Alireza","family":"Mousavi","sequence":"first","affiliation":[{"name":"International Campus\u2010School of Pharmacy Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Tehran University of Medical Sciences Tehran 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