{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:01:51Z","timestamp":1790892111573,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Curcumin, a natural compound with broad pharmacological effects, suffers from low bioavailability due to its unstable \u03b2\u2010diketone structure. To address this, we designed novel indole\u2010based curcumin analogs via molecular hybridization, replacing the \u03b2\u2010diketone with a monocarbonyl bridge to enhance stability. A series of symmetric (\n                    <jats:bold>1a<\/jats:bold>\n                    and\n                    <jats:bold>1b<\/jats:bold>\n                    ) and asymmetric (\n                    <jats:bold>3a<\/jats:bold>\n                    \u2013\n                    <jats:bold>3i<\/jats:bold>\n                    ) compounds were synthesized. The antioxidant assays (DPPH method) revealed a concentration\u2010dependent radical scavenging effect, with compound\n                    <jats:bold>3e<\/jats:bold>\n                    exhibiting 23.1% inhibition at 64\u2009\u03bcM. In vitro antitumor screening using the MTT assay across four human cancer cell lines (Eca109, SMMC7721, A549, and MGC803) revealed promising inhibitory effects. Among them, compound\n                    <jats:bold>1a<\/jats:bold>\n                    displayed the most potent activity against Eca109 cells, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 6.84\u2009\u03bcM, being markedly lower than those of curcumin (29.5\u2009\u03bcM) and cisplatin (10.4\u2009\u03bcM), indicating superior cytotoxicity. Molecular docking analysis of\n                    <jats:bold>1a<\/jats:bold>\n                    predicted strong binding to EGFR (\u201310.9\u2009kcal\/mol) and CDK6 (\u201311.2\u2009kcal\/mol), stabilized by hydrogen bonds and hydrophobic interactions. These results validate the novelty of indole modification and correlate in vitro activity with in silico mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70228","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:01:34Z","timestamp":1774418494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Indole\u2010Based Curcumin Analogs With Antioxidant and Antitumor Activities: Synthesis, Molecular Docking"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1853-4480","authenticated-orcid":false,"given":"Zhipeng","family":"Huang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongming","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangchun","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600760506"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(01)00194-7"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence From Molecular Mechanisms to Clinical Outcomes","volume":"179","author":"Mohammadian Haftcheshmeh S.","year":"2021","journal-title":"Reviews of Physiology, Biochemistry and Pharmacology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072364"},{"key":"e_1_2_7_6_1","first-page":"632","article-title":"Preliminary Study on Antirheumatic Activity of Curcumin (Diferuloyl Methane)","volume":"71","author":"Dcodhar S. 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