{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:35:47Z","timestamp":1789104947271,"version":"build-2803163510"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/1307 (16134)\/2022\u2010EMR\u20101"],"award-info":[{"award-number":["09\/1307 (16134)\/2022\u2010EMR\u20101"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chalcones are versatile scaffolds with broad pharmacological relevance, particularly as anti\u2010inflammatory and anti\u2010malarial agents. In the current investigation, a series of (3\u2010arylediene\u20101\u2010phenyl\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u2010pyrazol\u20104\u2010yl)acryloyl\u20104\u2010hydroxy\u20106\u2010methyl\u20102\n                    <jats:italic>H<\/jats:italic>\n                    \u2010pyran\u20102\u2010one analogs\/1,3\u2010diarylprop\u20102\u2010en\u20101\u2010ones were successfully synthesized, leveraging dehydroacetic acid (DHA) as the precursor molecule. The choice of DHA is strategic as it is a bioactive and highly versatile scaffold bearing a 4\u2010hydroxy\u20106\u2010methyl\u20102\n                    <jats:italic>H<\/jats:italic>\n                    \u2010pyran\u20102\u2010one moiety, which enhances structural diversity and provides multiple reactive sites for functionalization. Its inherent anti\u2010microbial, anti\u2010inflammatory, and anti\u2010malarial potential offers an added advantage over conventional precursors, thereby increasing the likelihood of generating pharmacologically active chalcone hybrids. The synthetic protocol employed in this study involved the implementation of a Claisen condensation reaction, wherein DHA was reacted with formyl pyrazole to afford the corresponding chalcones, with yields ranging from moderate to good. The synthesized compounds were subjected to a rigorous characterization protocol, involving a battery of analytical techniques, including\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR, FT\u2010IR, and HRMS analyses. Biological evaluation focused on anti\u2010malarial and anti\u2010inflammatory activities, while molecular docking (PyRx 0.8) was performed to explore binding interactions with cyclooxygenase\u20102 (COX\u20102; PDB ID: 3LN1) and enoyl\u2010acyl\u2010carrier\u2010protein reductase (EACPR; PDB ID: 1NHG). Notably, compound\n                    <jats:bold>3c<\/jats:bold>\n                    emerged as the most potent one within the synthesized series, exhibiting remarkable anti\u2010inflammatory and anti\u2010malarial potency, as evidenced by its IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 7.05\u2009\u00b1\u20090.17\u2009\u00b5M and 0.95\u2009\u00b1\u20090.06\u2009\u00b5M, respectively. Docking studies revealed strong binding affinities and favorable molecular interactions, supporting the observed bioactivities. This study highlights chalcone\u2013pyrazole hybrids as promising therapeutic scaffolds. In particular, compound\n                    <jats:bold>3c<\/jats:bold>\n                    emerges as a compelling lead candidate for further optimization and preclinical investigation as a dual\u2010action agent against malaria and inflammation.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70231","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:01:58Z","timestamp":1775714518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and Synthesis of Bioactive (3\u2010Arylediene\u20101\u2010phenyl\u20101\n                    <i>H<\/i>\n                    \u2010pyrazol\u20104\u2010yl)acryloyl\u20104\u2010hydroxy\u20106\u2010methyl\u20102\n                    <i>H<\/i>\n                    \u2010pyran\u20102\u2010ones With Anti\u2010Malarial and Anti\u2010Inflammatory Activities"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0852-6170","authenticated-orcid":false,"given":"Priyanka","family":"Rani","sequence":"first","affiliation":[{"name":"Department of Chemistry Chaudhary Bansi Lal University Bhiwani Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chaudhary Bansi Lal University Bhiwani Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginna","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chaudhary Bansi Lal University Bhiwani Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Chahal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chaudhary Bansi Lal University Bhiwani Haryana 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