{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:25:56Z","timestamp":1790623556939,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This work is designed to establish sustainable routes for the synthesis of new variable azo heterocyclic derivatives via the reaction of 2\u2010[(dicyanomethyl)diazinyl]benzoic acid\n                    <jats:bold>2<\/jats:bold>\n                    with different nucleophilic agents, including hydrazine derivatives (such as phenyl hydrazine and 2,4\u2010dinitrophenylhydrazine), acylhydrazines (e.g., benzoylhydrazine), nitrogen\u2010based nucleophiles (semicarbazide and thiosemicarbazide), oxygen\u2010containing reagents (hydroxylamine), as well as urea, thiourea, guanidine hydrochloride, and\n                    <jats:italic>o<\/jats:italic>\n                    \u2010phenylenediamine. Both conventional heating and microwave approaches were used to furnish the desired heterocycles. The compounds exhibited potent antibacterial activity against Gram\u2010positive and Gram\u2010negative pathogens, outperforming fluconazole. The lead compound was successfully radiolabeled with\n                    <jats:sup>131<\/jats:sup>\n                    I in high yield (87.72% RCY). In vivo evaluation in an infection model demonstrated excellent pharmacokinetics, with specific uptake in infected tissue (13.7% ID\/g at 1\u2009h) and a high target\u2010to\u2010non\u2010target ratio (6.31). These findings underscore the theranostic potential of these azo compounds, positioning them as both antimicrobial agents and candidate radiotherapeutics for infection.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70245","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:53:08Z","timestamp":1776675188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ecofriendly Synthesis of New Azo Compounds as Antibacterial Agents: In Vitro Screening and Preliminary In Vivo Evaluation Using\n                    <sup>131<\/sup>\n                    I\u2010Radiolabeling"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3017-8806","authenticated-orcid":false,"given":"Kurls E.","family":"Anwer","sequence":"first","affiliation":[{"name":"Heterocyclic Synthesis Lab, Chemistry Department Faculty of Science, Ain Shams University, Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma M.","family":"Essa","sequence":"additional","affiliation":[{"name":"Radioactive Isotopes and Generator Department Hot Laboratories Centre, Egyptian Atomic Energy Authority (EAEA) Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-5978","authenticated-orcid":false,"given":"Adli A.","family":"Selim","sequence":"additional","affiliation":[{"name":"Labeled Compounds Department Hot Laboratories Centre, Egyptian Atomic Energy Authority (EAEA) Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galal H.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Heterocyclic Synthesis Lab, Chemistry Department Faculty of Science, Ain Shams University, Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa S.","family":"Shaban","sequence":"additional","affiliation":[{"name":"Heterocyclic Synthesis Lab, Chemistry Department Faculty of Science, Ain Shams University, Abbassia Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"01","key":"e_1_2_7_2_1","first-page":"144","article-title":"Azo Compounds and Their Potential Applications: Article Review, Al\u2010Kitab","volume":"9","author":"Al\u2010Majdi Z. 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