{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:02:29Z","timestamp":1789491749842,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Angiogenesis, regulated by vascular endothelial growth factor (VEGF), is crucial in tumor growth, metastasis, and inflammation.\n                    <jats:italic>Leonurus japonicus<\/jats:italic>\n                    Houtt., a traditional Chinese herb, was investigated for its anti\u2010angiogenic potential. DNA sequencing confirmed its identity, distinguishing it from the common morphological misidentification with\n                    <jats:italic>Leonurus sibiricus<\/jats:italic>\n                    by the public. Using UHPLC\u2010MS\/MS and GNPS (Global Natural Products Social) molecular networking on the active methanol partition, over 6000 nodes were grouped into 273 clusters. Diterpenoids and flavonoids were targeted. Six compounds were successfully isolated from\n                    <jats:italic>L. japonicus<\/jats:italic>\n                    , including four labdane\u2010type diterpenoids (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ) and two flavonoids (\n                    <jats:bold>5<\/jats:bold>\n                    ,\n                    <jats:bold>6<\/jats:bold>\n                    ) using column chromatography. Compound\n                    <jats:bold>1<\/jats:bold>\n                    , (\u2013)\u20108\n                    <jats:italic>S<\/jats:italic>\n                    \u2010acetoxy\u201015,16\u2010epoxy\u20108,9\u2010seco\u201013(16),14\u2010labdadiene, was a new stereoisomer, while Compound\n                    <jats:bold>6<\/jats:bold>\n                    , nevadensin, was reported for the first time from this species. Compounds were characterized by NMR, ESI\u2010MS, and ECD. At 50\u2009\u03bcM, Compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    exhibited inhibitory effects in endothelial progenitor cell (EPC) tube formation. Molecular docking and dynamics simulations supported this anti\u2010angiogenic activity. Compound\n                    <jats:bold>1<\/jats:bold>\n                    showed the highest VEGFR\u20102 binding affinity (\u22129.24\u2009kcal\/mol), comparable to sunitinib (\u22129.52\u2009kcal\/mol), further verified by an immunoblotting assay. This study demonstrated the successful integration of GNPS and bioactivity\u2010guided isolation for identifying natural VEGFR\u20102 inhibitors. Our findings highlight Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    as promising lead candidates for anti\u2010angiogenic therapy.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70249","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:33:54Z","timestamp":1786613634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of VEGFR\u20102 Inhibitors From\n                    <i>Leonurus japonicus<\/i>\n                    via Integrated Genetic Authentication, Molecular Networking, and In Silico Analysis"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7548-4497","authenticated-orcid":false,"given":"Thiyagarajan","family":"Raviraj","sequence":"first","affiliation":[{"name":"Graduate Institute of Natural Products, College of 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