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The synthesized stereoisomeric hydroxamic acids were tested for antibacterial activity as well as inhibitory potency toward the bacterial deacetylase LpxC, a promising target for antibiotics selectively targeting Gram\u2010negative bacteria. The obtained biological data were compared with those of the previously synthesized 12 stereoisomers, and molecular docking as well as molecular dynamics studies were performed to rationalize the observed structure\u2013activity relationships. 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