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It has garnered increasing scientific attention not only due to its ecological significance but also for its rich diversity of bioactive compounds. Research has revealed that its tissues, particularly the dermal layer, contain a diverse array of biologically active metabolites, including saponins, steroids, terpenoids, alkaloids, fatty acids, and sphingolipids, many of which exhibit anti\u2010inflammatory, cytotoxic, antioxidant, and antimicrobial properties. These bioactive metabolites have highlighted\n                    <jats:italic>A. planci<\/jats:italic>\n                    as a potentially valuable source for novel natural product discovery. Furthermore, its exceptional regenerative abilities make it a promising organism for studies in regenerative biology and marine biotechnology. The present review compiles up\u2010to\u2010date findings on\n                    <jats:italic>A. planci<\/jats:italic>\n                    's pharmacologically significant metabolites and underscores its emerging role in biomedical and pharmaceutical research.\n                  <\/jats:p>","DOI":"10.1002\/ardp.70286","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:08:47Z","timestamp":1783080527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Marine Starfish\n                    <i>Acanthaster planci<\/i>\n                    : Secondary Metabolites and Pharmacological Activities"],"prefix":"10.1002","volume":"359","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2352-8738","authenticated-orcid":false,"given":"Salma A.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Galala University  New Galala Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3574-5518","authenticated-orcid":false,"given":"Mahmoud A.","family":"Elrebehy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Galala University  New Galala Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina M.","family":"Hal","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-9954","authenticated-orcid":false,"given":"Amira Abdel","family":"Motaal","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Galala University  New Galala Egypt"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-0044","authenticated-orcid":false,"given":"Amany K.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5949-2497","authenticated-orcid":false,"given":"Asma Ahmad","family":"Nashawi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5357-2653","authenticated-orcid":false,"given":"Mohammed A.","family":"Baradwan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-4546","authenticated-orcid":false,"given":"Samar S. 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